Molecular structure of IDRA 21, CAS Number: 67483-13-0
IDRA 21 (CAS 22503-72-6)
Alternate Names:
7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Application:
IDRA 21 is an analog of cyclothiazide that Inhibits AMPA receptor desensitization
CAS Number:
22503-72-6
Molecular Weight:
232.69
Molecular Formula:
C8H9ClN2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IDRA 21 is an analog of cyclothiazide (sc-202560). IDRA 21 inhibits AMPA receptor desensitization. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
IDRA 21 (CAS 22503-72-6) References
- The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys. | Buccafusco, JJ., et al. 2004. Neuropharmacology. 46: 10-22. PMID: 14654093
- IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. | Losi, G., et al. 2004. Neuropharmacology. 46: 1105-13. PMID: 15111017
- The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. | Malkova, L., et al. 2011. Neuropharmacology. 60: 1262-8. PMID: 21185313
- 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. | Thompson, DM., et al. 1995. Proc Natl Acad Sci U S A. 92: 7667-71. PMID: 7644474
- 7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization. | Zivkovic, I., et al. 1995. J Pharmacol Exp Ther. 272: 300-9. PMID: 7815345
- Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus. | Bertolino, M., et al. 1993. Recept Channels. 1: 267-78. PMID: 7915948
- Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices. | Arai, A., et al. 1996. Neuroreport. 7: 2211-5. PMID: 8930991
- 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity. | Impagnatiello, F., et al. 1997. Proc Natl Acad Sci U S A. 94: 7053-8. PMID: 9192690
- The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury. | Yamada, KA., et al. 1998. Ann Neurol. 43: 664-9. PMID: 9585363
- The diazoxide derivative 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide augments AMPA- and GABA-mediated synaptic responses in cultured hippocampal neurons. | Yamada, KA., et al. 1998. Neurobiol Dis. 5: 196-205. PMID: 9848091
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IDRA 21, 5 mg | sc-202659 | 5 mg | $72.00 | |||
IDRA 21, 25 mg | sc-202659A | 25 mg | $246.00 |