Molecular structure of Idebenone, CAS Number: 58186-27-9
Idebenone (CAS 58186-27-9)
See product citations (2)
Alternate Names:
2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Application:
Idebenone is an antioxidant and neuroprotective agent
CAS Number:
58186-27-9
Purity:
≥98%
Molecular Weight:
338.44
Molecular Formula:
C19H30O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Idebenone, a neuroprotective agent, may act to act as a free radical scavenger and protect mitochondrial membranes against lipid peroxidation. This compound has also been found to prevent platelet aggregation and recover cholinergic and monoaminergic changes in murine models. Other studies show that Idebenone displays a capacity to increase nerve growth factor production in cultured rat astrocytes. Additionally, this agent has been reported to dose-dependently inhibit enzymatic metabolism of Arachidonic Acid (sc-200770) in astroglial homogenates.
Idebenone (CAS 58186-27-9) References
- Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. | Civenni, G., et al. 1999. Eur J Pharmacol. 370: 161-7. PMID: 10323265
- CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production. | Takuma, K., et al. 2000. Eur J Pharmacol. 406: 333-9. PMID: 11040339
- Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review. | Zs -Nagy, I. 1990. Arch Gerontol Geriatr. 11: 177-86. PMID: 15374467
- Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson's Disease Mice. | Yan, A., et al. 2018. Front Cell Neurosci. 12: 529. PMID: 30687016
- Esculetin and idebenone ameliorate galactose-induced cataract in a rat model. | Sadik, NAH., et al. 2020. J Food Biochem. 44: e13230. PMID: 32301145
- Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway. | Jiang, W., et al. 2021. Cardiovasc Drugs Ther. 35: 1129-1145. PMID: 32557012
- Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity. | Hui, C., et al. 2020. Biomed Pharmacother. 132: 110823. PMID: 33045613
- Idebenone Ameliorates Rotenone-Induced Parkinson's Disease in Rats Through Decreasing Lipid Peroxidation. | Avcı, B., et al. 2021. Neurochem Res. 46: 513-522. PMID: 33247801
- Protective Effects of Idebenone against Sepsis Induced Acute Lung Damage. | Akpinar, E., et al. 2022. J Invest Surg. 35: 560-568. PMID: 33722148
- Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD. | Lee, HJ., et al. 2021. Biology (Basel). 10: PMID: 34571815
- Idebenone relieves the damage of heat stress on the maturation and developmental competence of porcine oocytes. | Shi, XY., et al. 2022. Reprod Domest Anim. 57: 418-428. PMID: 35014107
- Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice. | Yan, J., et al. 2022. Cell Death Discov. 8: 28. PMID: 35039479
- Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation. | Lee, HJ., et al. 2022. Front Immunol. 13: 749336. PMID: 35222363
- Idebenone-loaded wound dressings promote diabetic wound healing through downregulation of Il1b, Nfkb genes and upregulation of Fgf2 gene. | Jintao, Y. 2022. Res Vet Sci. 151: 128-137. PMID: 35901525
- Idebenone reduces sepsis-induced oxidative stress and apoptosis in hepatocytes via RAGE/p38 signaling. | Gou, T., et al. 2022. Ann Transl Med. 10: 1363. PMID: 36660726
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Idebenone, 20 mg | sc-200819 | 20 mg | $89.00 | |||
Idebenone, 100 mg | sc-200819A | 100 mg | $365.00 |