IDE 2 CAS: 1136466-93-7
MF: C12H20N2O3
MW: 240.30
An inducer of stem cell differentiation.

IDE 2 (CAS 1136466-93-7)

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Synonym: 7-(2-Cyclopentylidenehydrazinyl)-7-oxoheptanoic acid
Application: An inducer of stem cell differentiation
CAS Number: 1136466-93-7
Molecular Weight: 240.30
Molecular Formula: C12H20N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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IDE 2 is a cell-permeable molecule capable of directing differentiation of mouse and human embryonic stem cells into endodermal cells (EC50=223 nM). Developmental potential of these chemically derived endodermal cells has been shown via continued differentiation into pancreatic progenitor cells and incorporation into developing gut tubes of live mouse embryos. Nodal/Smad signaling is activated indicating IDE 2 functions via TGF-β-signaling pathway.


References

1. Borowiak, Malgorzata., et al., 2009. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell. 4(4): 348-58. PMID: 19341624

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23836158
SMILES :
C1CCC(=NNC(=O)CCCCCC(=O)O)C1

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