Molecular structure of IDE 2, CAS Number: 1136466-93-7
IDE 2 (CAS 1136466-93-7)
Application:
IDE 2 is an inducer of stem cell differentiation
CAS Number:
1136466-93-7
Molecular Weight:
240.30
Molecular Formula:
C12H20N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
IDE 2 is a cell-permeable molecule capable of directing differentiation of mouse and human embryonic stem cells into endodermal cells (EC50=223 nM). Developmental potential of these chemically derived endodermal cells has been shown via continued differentiation into pancreatic progenitor cells and incorporation into developing gut tubes of live mouse embryos. Nodal/Smad signaling is activated indicating IDE 2 functions via TGF-beta-signaling pathway.
IDE 2 (CAS 1136466-93-7) References
- Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. | Borowiak, M., et al. 2009. Cell Stem Cell. 4: 348-58. PMID: 19341624
- Embryonic stem cells of the non-human primate Callithrix jacchus can be differentiated into definitive endoderm by Activin-A but not IDE-1/2. | Diekmann, U., et al. 2015. J Tissue Eng Regen Med. 9: 473-9. PMID: 23418163
- Hepatic Differentiation of Marmoset Embryonic Stem Cells and Functional Characterization of ESC-Derived Hepatocyte-Like Cells. | Aravalli, RN., et al. 2020. Hepat Med. 12: 15-27. PMID: 32104112
- Genome and Metabolome MS-Based Mining of a Marine Strain of Aspergillus affinis. | Gonçalves, MFM., et al. 2021. J Fungi (Basel). 7: PMID: 34947073
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IDE 2, 1 mg | sc-397020 | 1 mg | $108.00 |