Idazoxan hydrochloride CAS: 79944-56-2
MF: C11H12N2O2•HCl
MW: 240.69
An α2-AR adrenoceptor antagonist and I2 imidazoline receptor agonist..

Idazoxan hydrochloride (CAS 79944-56-2)

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Synonym: (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
Application: An α2-AR adrenoceptor antagonist and I2 imidazoline receptor agonist.
CAS Number: 79944-56-2
Purity: >98%
Molecular Weight: 240.69
Molecular Formula: C11H12N2O2•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Idazoxan hydrochloride is an α2-AR adrenoceptor antagonist and potential I2 imidazoline receptor agonist. Also displays I1 imidazoline receptor antagonist activity. (pKi values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I1, I2, α 2A, α 2B, and α 2C receptors respectively).


References

1. Dabire, H. 1986. J. Pharmacol. 17 :113-118. PMID: 2875218
2. Michel, M.C., et al. 1992. Trends Pharmacol Sci. 13: 369-370. PMID: 1413085
3. Berdeu, D., et al. 1995. Eur. J. Pharmacol. 275: 91-98. PMID: 7774667
4. Eglen, RM., et al. 1998. Trends Pharmacol Sci. 19: 381-390. PMID: 9786027
5. Clarke, R.W., et al. 2000. Neuropharmacology. 39: 1904-1912. PMID: 10884571
6. Happe, H.K., et al. 2000. Eur. J. Pharmacol. 399: 17-27. PMID: 10876018
7. Bousquet, P., et al. 2000. Pharm. Acta Helv. 74: 205-209. PMID: 10812959

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), and phosphate buffered saline (50 mM).
Storage :
Store at room temperature
Refractive Index :
n20D ~1.67 (Predicted)
IC50 :
Plasmodium falciparum 7G8 : IC50 = 10 µM; Plasmodium falciparum HB3 : IC50 = 10 µM; Plasmodium falciparum GB4 : IC50 = 12.59 µM; Plasmodium falciparum W2 : IC50 = 12.59 µM; Plasmodium falciparum 3D7 : IC50 = 12.59 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
154494
MDL Number :
MFCD00069293
SMILES :
C1CN=C(N1)C2COC3=CC=CC=C3O2.Cl

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Certificate of Analysis

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Idazoxan hydrochloride  Product Citations

See how others have used Idazoxan hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 29633624  2018. Can. J. Physiol. Pharmacol. 96: 845-849.

PMID: # 26435028  Kawamoto, S. et al. 2015. Eur. J. Pharmacol. 766: 122-8.

Citations 1 to 2 of 2 total
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