Molecular structure of Idazoxan hydrochloride, CAS Number: 79944-56-2
Idazoxan hydrochloride (CAS 79944-56-2)
See product citations (2)
Alternate Names:
(±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
Application:
Idazoxan hydrochloride is an α2-AR adrenoceptor antagonist and I2 imidazoline receptor agonist.
CAS Number:
79944-56-2
Purity:
>98%
Molecular Weight:
240.69
Molecular Formula:
C11H12N2O2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Idazoxan hydrochloride is an α2-AR adrenoceptor antagonist and potential I2 imidazoline receptor agonist. Also displays I1 imidazoline receptor antagonist activity. (pKi values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I1, I2, α 2A, α 2B, and α 2C receptors respectively).
Idazoxan hydrochloride (CAS 79944-56-2) References
- Imidazoline receptors: a challenge. | Bousquet, P., et al. 2000. Pharm Acta Helv. 74: 205-9. PMID: 10812959
- Alpha(2)-adrenoceptor-stimulated GTP gamma S binding in rat brain: an autoradiographic study. | Happe, HK., et al. 2000. Eur J Pharmacol. 399: 17-27. PMID: 10876018
- Imidazoline I(2)-receptors and spinal reflexes in the decerebrated rabbit. | Clarke, RW., et al. 2000. Neuropharmacology. 39: 1904-12. PMID: 10884571
- Keeping an eye on the I site: imidazoline-preferring receptors. | Michel, MC. and Ernsberger, P. 1992. Trends Pharmacol Sci. 13: 369-70. PMID: 1413085
- Antineoplastic activity of idazoxan hydrochloride. | Eilon, GF., et al. 2009. Cancer Chemother Pharmacol. 64: 1157-63. PMID: 19308411
- Idazoxan: a novel pharmacological tool for the study of alpha 2-adrenoceptors. | Dabiré, H. 1986. J Pharmacol. 17: 113-8. PMID: 2875218
- β2 and α2 adrenergic receptors mediate the proneurogenic in vitro effects of norquetiapine. | Bortolotto, V., et al. 2021. Neural Regen Res. 16: 2041-2047. PMID: 33642392
- Prolonged efficacy of cefazolin in intraosseous regional prophylaxis for total knee arthroplasty: a rabbit model study. | Zhang, JY., et al. 2024. BMC Musculoskelet Disord. 25: 106. PMID: 38302937
- Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. | Berdeu, D., et al. 1995. Eur J Pharmacol. 275: 91-8. PMID: 7774667
- 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. | Eglen, RM., et al. 1998. Trends Pharmacol Sci. 19: 381-90. PMID: 9786027
Inhibitor of:
alpha2A-AR, alpha2B-AR, and alpha2C-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Idazoxan hydrochloride, 10 mg | sc-204006 | 10 mg | $128.00 | |||
Idazoxan hydrochloride, 50 mg | sc-204006A | 50 mg | $505.00 |