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ICI 89406 (CAS 53671-71-9)

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Alternate Names:
N-[2-[3-(2-Cyanophenoxy)-2-hydroxypropylamino]ethyl]-N′-phenylurea
Application:
ICI 89406 is a β-adrenergic antagonist
CAS Number:
53671-71-9
Purity:
≥98%
Molecular Weight:
354.41
Molecular Formula:
C19H22N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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ICI 89406, known in the research context for its selective inhibition of aromatase, plays a pivotal role in the study of estrogen synthesis and its subsequent effects on various physiological processes. This compound has garnered attention for its efficacy in selectively targeting the aromatase enzyme, which is in the conversion of androgens to estrogens, a key step in the biosynthesis of these hormones. By inhibiting this enzyme, ICI 89406 provides a powerful tool for researchers to dissect the complex roles of estrogens in different biological systems, including their influence on gene expression, cellular proliferation, and differentiation. Its mechanism of action involves binding to the aromatase enzyme in a competitive manner, thus reducing the enzyme′s activity and affecting the levels of estrogen produced. This attribute makes ICI 89406 invaluable in studies aimed at understanding the intricate balance of hormone regulation and its implications in various physiological and pathological conditions.


ICI 89406 (CAS 53671-71-9) References

  1. Synthesis and evaluation of (S)-[18F]-fluoroethylcarazolol for in vivo beta-adrenoceptor imaging in the brain.  |  Doze, P., et al. 2002. Neurochem Int. 41: 17-27. PMID: 11918968
  2. Mechanisms of leptin secretion from white adipocytes.  |  Cammisotto, PG. and Bukowiecki, LJ. 2002. Am J Physiol Cell Physiol. 283: C244-50. PMID: 12055093
  3. Pre- and postnatal developmental changes of adrenoceptor subtypes in rat brain.  |  Erdtsieck-Ernste, BH., et al. 1991. J Neurochem. 57: 897-903. PMID: 1677680
  4. The characterization of beta adrenoceptor subtypes in the rat amygdala and hippocampus.  |  Tiong, AH. and Richardson, JS. 1990. Int J Neurosci. 54: 231-44. PMID: 1979972
  5. Age-related subsensitivity of cerebellar Purkinje neurons to locally applied beta 1-selective adrenergic agonist.  |  Parfitt, KD. and Bickford-Wimer, P. 1990. Neurobiol Aging. 11: 591-6. PMID: 1980720
  6. Noradrenergic innervation does not affect chronic regulation of [125I]pindolol receptors in fetal rat brain transplants or host neocortex.  |  Levin, BE. and Dunn-Meynell, A. 1989. Brain Res. 494: 325-38. PMID: 2550108
  7. Functional characterization of beta-adrenoceptor subtypes in rabbit right atria.  |  Tenner, TE., et al. 1989. Life Sci. 44: 651-60. PMID: 2564611
  8. Beta 3-adrenergic receptors are responsible for the adrenergic inhibition of insulin-stimulated glucose transport in rat adipocytes.  |  Carpéné, C., et al. 1993. Biochem J. 296 (Pt 1): 99-105. PMID: 7902704
  9. Effects of chronic antidepressant treatment on beta-adrenoceptor subtype binding in the rat cerebral cortex and cerebellum.  |  Paetsch, PR. and Greenshaw, AJ. 1993. Mol Chem Neuropathol. 20: 21-31. PMID: 7902719
  10. Coexisting beta-adrenoceptor subtypes: significance for thermogenic process in brown fat cells.  |  Zhao, J., et al. 1994. Am J Physiol. 267: C969-79. PMID: 7943293
  11. Effects of age and endurance training on beta-adrenergic receptor characteristics in Fischer 344 rats.  |  Mazzeo, RS., et al. 1995. Mech Ageing Dev. 84: 157-69. PMID: 8788243
  12. The beta 1- and beta 2-adrenoceptor subtypes in cultured rat inner medullary collecting duct cells.  |  Yasuda, G., et al. 1996. Am J Physiol. 271: F762-9. PMID: 8853440
  13. Lack of pineal beta-adrenergic receptor alterations in suicide victims with major depression.  |  Little, KY., et al. 1997. Psychoneuroendocrinology. 22: 53-62. PMID: 9141151
  14. Role of beta1- and beta3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes.  |  Atgié, C., et al. 1997. Am J Physiol. 273: C1136-42. PMID: 9357756
  15. Thermogenesis is beta3- but not beta1-adrenergically mediated in rat brown fat cells, even after cold acclimation.  |  Zhao, J., et al. 1998. Am J Physiol. 275: R2002-11. PMID: 9843890

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ICI 89406, 10 mg

sc-361212
10 mg
$91.00

ICI 89406, 50 mg

sc-361212A
50 mg
$520.00