ICAM-1/CD54 Antibody (5K16): sc-71303

ICAM-1 Antibody (5K16) is a rat monoclonal IgG2b antibody demonstrating reactivity with mouse species, suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-1, also known as CD54 or intercellular adhesion molecule-1, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. ICAM-1 plays a crucial role in immune responses by mediating cell-cell adhesion through interactions with leukocyte integrins like LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). These interactions facilitate the adhesion and transmigration of leukocytes across the endothelium during inflammation, which is essential for immune surveillance and host defense mechanisms. ICAM-1 expression is upregulated in response to pro-inflammatory cytokines, making ICAM-1 a key molecule in inflammatory processes. Dysregulation of ICAM-1 is associated with various pathological conditions, including autoimmune diseases, cardiovascular disorders, and cancer metastasis. Understanding ICAM-1 function is important for developing therapeutic strategies targeting inflammation and immune responses. Anti-ICAM-1 antibody (5K16) provides a valuable tool for studying ICAM-1 expression, localization, and function in physiological and pathological contexts.

The preferred ICAM-1/CD54 antibody is ICAM-1/CD54 Antibody (G-5): sc-8439.