Date published: 2026-4-24

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ICA 110381 (CAS 325457-99-6)

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Alternate Names:
4-Chloro-N-(6-chloro-3-pyridinyl)-benzamide
CAS Number:
325457-99-6
Molecular Weight:
267.11
Molecular Formula:
C12H8Cl2N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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ICA 110381 is a compound that has garnered attention for its role in research centered around ion channel modulation. It is particularly noted for its ability to selectively modulate certain potassium channels, which is a focus of study in neurological research due to the channels′ importance in regulating neuronal excitability. Investigations into ICA 110381 have included its effects on neurotransmitter release and its potential implications for understanding the mechanisms underlying neuronal synchronization. In research models, ICA 110381 has been used to elucidate the role of specific potassium channels in maintaining the resting membrane potential and action potential propagation in neurons. Additionally, its influence on the activity of these channels has been observed to provide insights into the modulation of electrical signaling in the central nervous system.


ICA 110381 (CAS 325457-99-6) References

  1. The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.  |  Boehlen, A., et al. 2013. Br J Pharmacol. 168: 1182-200. PMID: 23176257
  2. Atomic basis for therapeutic activation of neuronal potassium channels.  |  Kim, RY., et al. 2015. Nat Commun. 6: 8116. PMID: 26333338
  3. Histamine induces KCNQ channel-dependent gamma oscillations in rat hippocampus via activation of the H1 receptor.  |  Andersson, R., et al. 2017. Neuropharmacology. 118: 13-25. PMID: 28274820
  4. Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites.  |  Miceli, F., et al. 2018. Curr Med Chem. 25: 2637-2660. PMID: 29022505
  5. Activation of KCNQ (KV7) K+ channels in enteric neurons inhibits epithelial Cl- secretion in mouse distal colon.  |  Nickerson, AJ., et al. 2021. Am J Physiol Cell Physiol. 320: C1074-C1087. PMID: 33852365
  6. Chemical modulation of Kv7 potassium channels.  |  Borgini, M., et al. 2021. RSC Med Chem. 12: 483-537. PMID: 34046626
  7. Ligand modulation of KCNQ-encoded (KV7) potassium channels in the heart and nervous system.  |  Naffaa, MM. and Al-Ewaidat, OA. 2021. Eur J Pharmacol. 906: 174278. PMID: 34174270
  8. Regulation of Hippocampal Gamma Oscillations by Modulation of Intrinsic Neuronal Excitability.  |  Klemz, A., et al. 2021. Front Neural Circuits. 15: 778022. PMID: 35177966
  9. Spike Afterhyperpolarizations Govern Persistent Firing Dynamics in Rat Neocortical and Hippocampal Pyramidal Cells.  |  Cui, ED., et al. 2022. J Neurosci. 42: 7690-7706. PMID: 36414011
  10. Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability.  |  Estacion, M., et al. 2023. Front Pharmacol. 14: 1138556. PMID: 36923357

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ICA 110381, 10 mg

sc-488045
10 mg
$250.00