ICA 069673 CAS: 582323-16-8
MF: C11H6ClF2N3O
MW: 269.63
A selective activator of the KCNQ2/Q3 potassium channel.

ICA 069673 (CAS 582323-16-8)

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Alternate Names: N-(2-Chloro-5-pyrimidinyl)-3,4-difl uorobenzamide
Application: ICA 069673 is a selective activator of the KCNQ2/Q3 potassium channel
CAS Number: 582323-16-8
Molecular Weight: 269.63
Molecular Formula: C11H6ClF2N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

ICA 069673 is a potassium channel opener with selective action for KCNQ2 and KCNQ3 (EC50=0.69 μM). No meeasurable activity was displayed over a variety of cardiac ion channels.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (25 mM).
Storage :
Store at room temperature
Melting Point :
167.15° C (Predicted)
Boiling Point :
~358.9° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3): EC5050 = 0.69 µM (human); HERG: IC50 >30 µM (human); Na+ CP type Vα: IC50 >30 µM (human)
pK Values :
pKa: 9.47 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10149311
MDL Number :
MFCD20926351
SMILES :
C1=CC(=C(C=C1C(=O)NC2=CN=C(N=C2)Cl)F)F

Download SDS (MSDS)

Certificate of Analysis

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