Date published: 2025-10-16

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Iberin (CAS 505-44-2)

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Alternate Names:
3-Methylsulfinylpropyl isothiocyanate
Application:
Iberin is a phase II detoxification enzyme inducer
CAS Number:
505-44-2
Purity:
≥97%
Molecular Weight:
163.26
Molecular Formula:
C5H9NOS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Iberin, a sulfur-containing compound found in cruciferous vegetables such as broccoli, cabbage, and Brussels sprouts, is an intriguing subject of research due to its biochemical properties and potential roles in various scientific studies. As an isothiocyanate, iberin is known for its unique mechanism of action, which involves the modification of cysteine residues in proteins through a process known as alkylation. This modification can affect the activity of enzymes and other proteins, leading to alterations in cellular processes. Specifically, iberin has been extensively studied for its ability to modulate signaling pathways related to oxidative stress and inflammation, making it a compound of interest in research areas focused on cellular defense mechanisms and the regulation of gene expression. Its role in research extends to investigations into its effects on the cellular detoxification processes, where iberin is thought to induce the expression of phase II detoxifying enzymes, contributing to the understanding of cellular protective strategies against environmental stressors. The research on iberin, thus, provides valuable insights into its potential impact on cellular health and resilience, emphasizing its relevance in the broader context of biochemical and molecular biology studies.


Iberin (CAS 505-44-2) References

  1. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds.  |  Munday, R. and Munday, CM. 2004. J Agric Food Chem. 52: 1867-71. PMID: 15053522
  2. Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells.  |  Wang, W., et al. 2005. J Agric Food Chem. 53: 1417-21. PMID: 15740016
  3. Quantitative measurement of sulforaphane, iberin and their mercapturic acid pathway metabolites in human plasma and urine using liquid chromatography-tandem electrospray ionisation mass spectrometry.  |  Al Janobi, AA., et al. 2006. J Chromatogr B Analyt Technol Biomed Life Sci. 844: 223-34. PMID: 16931178
  4. Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1).  |  Traka, MH., et al. 2009. Nutr Cancer. 61: 137-45. PMID: 19116884
  5. Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure.  |  Chambers, KF., et al. 2009. Prostate. 69: 1411-21. PMID: 19489030
  6. Improvement in determination of isothiocyanates using high-temperature reversed-phase HPLC.  |  Wilson, EA., et al. 2012. J Sep Sci. 35: 2026-31. PMID: 22752995
  7. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin.  |  Ernst, IM., et al. 2013. Pharmacol Res. 70: 155-62. PMID: 23403058
  8. Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa.  |  Tan, SY., et al. 2014. Antimicrob Agents Chemother. 58: 6648-59. PMID: 25155599
  9. Bioavailability of Isothiocyanates From Broccoli Sprouts in Protein, Lipid, and Fiber Gels.  |  Oliviero, T., et al. 2018. Mol Nutr Food Res. 62: e1700837. PMID: 29532635
  10. Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization.  |  Pocasap, P., et al. 2019. Biomol Ther (Seoul). 27: 540-552. PMID: 31405267
  11. Direct HPLC enantioseparation of chemopreventive chiral isothiocyanates sulforaphane and iberin on immobilized amylose-based chiral stationary phases under normal-phase, polar organic and aqueous conditions.  |  Panusa, A., et al. 2020. Talanta. 218: 121151. PMID: 32797906
  12. Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression.  |  Gong, TT., et al. 2021. Biomed Pharmacother. 142: 111533. PMID: 34148735
  13. Composition of the Gut Microbiome Influences Production of Sulforaphane-Nitrile and Iberin-Nitrile from Glucosinolates in Broccoli Sprouts.  |  Bouranis, JA., et al. 2021. Nutrients. 13: PMID: 34578891
  14. The Anti-Inflammatory Effects of Iberin on TNF-α-Stimulated Human Oral Epithelial Cells: In Vitro Research.  |  Hosokawa, Y., et al. 2022. Biomedicines. 10: PMID: 36551911

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Iberin, 10 mg

sc-205718
10 mg
$230.00

Iberin, 25 mg

sc-205718A
25 mg
$520.00