Date published: 2026-4-24

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Ibandronate sodium salt (CAS 138844-81-2)

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Alternate Names:
(1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium; Bondronat
Application:
Ibandronate sodium salt is an inhibitor of FDPS (farnesyl diphosphate synthase) (IC50 = 20 nM)
CAS Number:
138844-81-2
Molecular Weight:
341.21
Molecular Formula:
C9H22NNaO7P2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ibandronate sodium salt, a bisphosphonate compound, is extensively studied in scientific research, particularly in the fields of bone biology, osteoporosis, and drug development. This chemical exerts its effects through inhibition of osteoclast-mediated bone resorption, a process crucial for maintaining bone density and strength. Ibandronate functions by binding to hydroxyapatite crystals in bone tissue, where it is internalized by osteoclasts and disrupts their function, leading to decreased bone turnover and increased bone mineral density. Researchers utilize Ibandronate sodium salt as a pharmacological tool to investigate the molecular mechanisms underlying bone remodeling and osteoclast activity regulation. Additionally, it serves as a lead compound in the development of novel bisphosphonate derivatives with enhanced efficacy and selectivity for bone-targeted therapies. Furthermore, Ibandronate sodium salt finds applications in studies to evaluate its effects on bone metabolism and fracture healing in animal models of osteoporosis and bone diseases. Its pivotal role in bone research and drug discovery highlights its significance as a tool for advancing our understanding of bone physiology and developing novel strategies for bone-related disorders.


Ibandronate sodium salt (CAS 138844-81-2) References

  1. Ibandronate: a potent new bisphosphonate in the management of postmenopausal osteoporosis.  |  Papapoulos, SE. 2003. Int J Clin Pract. 57: 417-22. PMID: 12846348
  2. A sensitive post-column photochemical derivatization/fluorimetric detection system for HPLC determination of bisphosphonates.  |  Pérez-Ruiz, T., et al. 2009. J Chromatogr A. 1216: 1312-8. PMID: 19150069
  3. Phosphatase inhibitors with anti-angiogenic effect in vitro.  |  Sylvest, L., et al. 2010. APMIS. 118: 49-59. PMID: 20041871
  4. Effects of bisphosphonates in combination with ionizing radiation and antioxidants on the growth of prostate and melanoma cells lines.  |  Alcaraz, M., et al. 2013. Anticancer Res. 33: 3217-24. PMID: 23898082
  5. Prediction of bioavailability of selected bisphosphonates using in silico methods towards categorization into a biopharmaceutical classification system.  |  Biernacka, J., et al. 2013. Acta Pol Pharm. 70: 877-82. PMID: 24147367
  6. The Electroporation as a Tool for Studying the Role of Plasma Membrane in the Mechanism of Cytotoxicity of Bisphosphonates and Menadione.  |  Šilkūnas, M., et al. 2016. J Membr Biol. 249: 611-621. PMID: 27044359
  7. Development and validation of a method using ultra performance liquid chromatography coupled to tandem mass spectrometry for determination of zoledronic acid concentration in human bone.  |  Lo Faro, AF., et al. 2019. J Pharm Biomed Anal. 162: 286-290. PMID: 30273818
  8. Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia.  |  Gadelha, APR., et al. 2020. Parasit Vectors. 13: 168. PMID: 32248823
  9. Toward developing a metastatic breast cancer treatment strategy that incorporates history of response to previous treatments.  |  Olow, AK., et al. 2021. BMC Cancer. 21: 212. PMID: 33648460

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ibandronate sodium salt, 10 mg

sc-215165
10 mg
$88.00

Ibandronate sodium salt, 50 mg

sc-215165A
50 mg
$338.00