Molecular structure of IB-MECA, CAS Number: 152918-18-8
IB-MECA (CAS 152918-18-8)
Alternate Names:
N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide
Application:
IB-MECA is a potent and selective Adenosine A3-R agonist
CAS Number:
152918-18-8
Purity:
≥97%
Molecular Weight:
510.29
Molecular Formula:
C18H19IN6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IB-MECA may act to act as a potent and selective Adenosine A3-R agonist with Ki values of 1.1, 54 and 56 nM for Adenosine A3-R, Adenosine A1-R and Adenosine A2A-R, respectively. This compound has demonstrated cardioprotective activity. IB-MECA, also known as A3 adenosine receptor agonist or N6-(3-iodobenzyl)adenosine-5′-N-methyluronamide, is a synthetic compound that acts as a selective agonist for the adenosine A3 receptor.
IB-MECA (CAS 152918-18-8) References
- Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA. | Lasley, RD., et al. 1999. Am J Physiol. 276: H2076-84. PMID: 10362690
- Adenosine receptors and their ligands. | Klotz, KN. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362: 382-91. PMID: 11111832
- First Synthesis of beta-D-Galf(1-4)GlcNAc, a Structural Unit Attached O-Glycosidically in Glycoproteins of Trypanosoma cruzi. | Gallo-Rodriguez, C., et al. 1996. J Org Chem. 61: 1886-1889. PMID: 11667072
- A3 adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs. | Auchampach, JA., et al. 2003. Am J Physiol Heart Circ Physiol. 285: H607-13. PMID: 12689858
- N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3 beta. | Park, SS., et al. 2006. J Pharmacol Exp Ther. 318: 124-31. PMID: 16611852
- IB-MECA, an A3 adenosine receptor agonist prevents bone resorption in rats with adjuvant induced arthritis. | Rath-Wolfson, L., et al. 2006. Clin Exp Rheumatol. 24: 400-6. PMID: 16956430
- IB-MECA and cardioprotection. | Xu, Z., et al. 2006. Cardiovasc Drug Rev. 24: 227-38. PMID: 17214599
- IB-MECA, an adenosine A(3) receptor agonist, does not influence survival of lethally γ-irradiated mice. | Hofer, M., et al. 2012. Physiol Res. 61: 649-54. PMID: 23098658
- Role of nitric oxide in the behavioral and neurochemical effects of IB-MECA in zebrafish. | Maximino, C., et al. 2015. Psychopharmacology (Berl). 232: 1671-80. PMID: 25388291
- The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A 2A receptors. | Tian, Y., et al. 2015. Basic Res Cardiol. 110: 16. PMID: 25711314
- Antinociceptive and neurochemical effects of a single dose of IB-MECA in chronic pain rat models. | Cioato, SG., et al. 2020. Purinergic Signal. 16: 573-584. PMID: 33161497
- Bioinformatic Analysis for Potential Biomarkers and Therapeutic Targets of T2DM-related MI. | Li, C. and Liu, Z. 2021. Int J Gen Med. 14: 4337-4347. PMID: 34413670
- A3 adenosine receptor agonist IB-MECA reverses chronic cerebral ischemia-induced inhibitory avoidance memory deficit. | Cheng, P., et al. 2022. Eur J Pharmacol. 921: 174874. PMID: 35278404
Activator of:
Adenosine A1-R, and Adenosine A3-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IB-MECA, 5 mg | sc-224020 | 5 mg | $276.00 | |||
IB-MECA, 25 mg | sc-224020A | 25 mg | $1215.00 |