IB-MECA has been shown to act as a potent and selective Adenosine A3-R agonist with Ki values of 1.1, 54 and 56 nM for Adenosine A3-R, Adenosine A1-R and Adenosine A2A-R, respectively. This compound has demonstrated cardioprotective activity.
1. Gallo-Rodriguez, C., et al. 1996. J. Org. Chem. 61: 1886-1889. PMID: 11667072 2. Klotz, K.N. 2000. Naunyn-Schmied. Arch. Pharmacol. 362: 382-391. PMID: 11111832 3. Park, S.S., et al. 2006. J. Pharmacol. Exp. Ther. 318: 124-131. PMID: 16611852
Soluble in DMSO (50 mM), and hot ethanol (>10 mg/ml). Insoluble in water, aqueous acid, and aqueous base.
Store at 4° C
1.98 g/cm3 (Predicted)
n20D 1.81 (Predicted)
Inhibition of isoproterenol-stimulated cAMP accumulation: EC5050 = 1 nM (HEK 293 cells expressing human Adenosine A3 receptor); Adenosine A3-R: IC50 = 1.2 nM (human); Effect on forskolin-stimulated cyclic AMP production: EC5050 = 3.6 nM (intact CHO cell expressing the human Adenosine A3 receptor); Activation of adenosine A2B receptor: EC5050 ≥10 µM (mouse); Effective concentration for cAMP production: EC5050 = 11 µM (CHO-KI cells stably transfected with human adenosine A2B receptor cDNA)
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