Molecular structure of I-OMe-Tyrphostin AG 538
I-OMe-Tyrphostin AG 538
See product citations (2)
Alternate Names:
α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone; I-OMe-AG 538
Molecular Weight:
437.19
Molecular Formula:
C17H12INO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
I-OMe-Tyrphostin AG 538 is an inhibitor of IGF-1 (insulin growth factor 1 receptor) protein tyrosine kinase. I-OMe-Tyrphostin AG 538 demonstrates potent inhibition of IGF-1R-mediated signaling and displays preferential cytotoxicity towards nutrient-deprived PANC1 cells. This compound acts as an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), exhibiting an IC50 value of 1 µM. Researchers have effectively employed I-OMe-Tyrphostin AG 538 as a cell signaling inhibitor in PC-1 cell lines. Furthermore, it has been utilized in high throughput screening assays to identify potential IGF1R inhibitors.
I-OMe-Tyrphostin AG 538 References
- Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling. | Ma, T., et al. 2009. J Neurosci. 29: 11226-36. PMID: 19741129
- A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. | Davis, MI., et al. 2013. PLoS One. 8: e54127. PMID: 23326584
- Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma. | Giudici, ML., et al. 2016. Adv Biol Regul. 61: 47-50. PMID: 26710750
- Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening. | Dunn, EA., et al. 2016. Data Brief. 6: 275-8. PMID: 26862571
- Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. | Pinheiro, BS., et al. 2016. Brain Res Bull. 124: 222-30. PMID: 27208730
- A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells. | Seo, HH., et al. 2017. Biol Res. 50: 1. PMID: 28100269
- Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions. | Garrett, SM., et al. 2019. PLoS One. 14: e0225422. PMID: 31765403
- Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. | Manz, TD., et al. 2020. ACS Med Chem Lett. 11: 346-352. PMID: 32184968
- A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules. | Zorn, KM., et al. 2021. ACS Infect Dis. 7: 406-420. PMID: 33434015
- Cell engineering method using fluorogenic oligonucleotide signaling probes and flow cytometry. | Shekdar, K., et al. 2021. Biotechnol Lett. 43: 949-958. PMID: 33683511
- Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT. | Brown, AS., et al. 2021. Pharmaceutics. 13: PMID: 34371757
- Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System*. | Janssen, GV., et al. 2021. Chembiochem. 22: 3082-3089. PMID: 34387015
- PIP kinases: A versatile family that demands further therapeutic attention. | Llorente, A., et al. 2023. Adv Biol Regul. 87: 100939. PMID: 36517396
Inhibitor of:
IGF-I.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
I-OMe-Tyrphostin AG 538, 5 mg | sc-300821 | 5 mg | $115.00 | |||
I-OMe-Tyrphostin AG 538, 50 mg | sc-300821B | 50 mg | $816.00 | |||
I-OMe-Tyrphostin AG 538, 100 mg | sc-300821C | 100 mg | $1428.00 |