I-OMe-Tyrphostin AG 538 MF: C17H12INO5
MW: 437.19

I-OMe-Tyrphostin AG 538

I-OMe-Tyrphostin AG 538 is rated 5.0 out of 5 by 1.
  • y_2020, m_2, d_27, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_300821, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 117ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone; I-OMe-AG 538
Molecular Weight: 437.19
Molecular Formula: C17H12INO5
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

I-OMe-Tyrphostin AG 538 is an inhibitor of IGF-1 (insulin growth factor 1 receptor) protein tyrosine kinase.


References

1. Blum, G., et al. 2000. Biochemistry. 39: 15705-15712. PMID: 11123895

Physical State :
Solid
Solubility :
Soluble in methanol, and DMSO (50 mg/ml).
Storage :
Store at -20° C
IC50 :
Intestinal alkaline phosphatase: IC50 = <195 nM (mouse); Intestinal alkaline phosphatase: IC50 = 4560 nM (human); Alkaline phosphatase, tissue-nonspecific isozyme: IC50 = 5880 nM (human); Large T antigen: IC50 = 7170 nM (Simian virus 40); IGF1R autophosphorylation: IC50 = ~3.4 µM; phosphorylation of poly: IC50 = ~2 µM
pK Values :
pKa: 7.46 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5353685
MDL Number :
MFCD03453582
SMILES :
COC1=C(C(=CC(=C1)/C=C(\\C#N)/C(=O)C2=CC(=C(C=C2)O)O)I)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 111ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Maturana Maturana-Teixeira S; et al. (PubMed ID: 25274047) utilized I-OMe-Tyrphostin AG 538 as an inhibitor of the IGF-I receptor to determine (Na(+)/K(+))-ATPase activity in rat retinas. -SCBT Publication Review
Date published: 2015-02-03
  • y_2020, m_2, d_27, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_300821, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.