Hypericin was originally isolated from Hypericum perforatum L. (St. John's Wort). Can be additionally isolated via irradiation of oxypenicilliopsin produced by Penicilliopsis clavariaeformis. A potent and selective inhibitor of PKC (protein kinase C) and additionally reported to inhibit Casein Kinase II (CKII), MAP Kinase, Insulin R, EGFR, PI-3 Kinase. Hypericin is also noted to possess antiviral activity and is of interest in HIV studies. Hypericin is of interest in studies investigating photodynamic treatment of tumors and has been reported to be cytotoxic to some tumor cell lines when Hypericin is photoactivated. Hypericin is an inhibitor of EGFR.
1. Meruelo, D., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85: 5230-5234. PMID: 2839837
2. Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165: 1207-1212. PMID: 2558652
3. Solár, P., et al. 2011. Radiat. Res. 175: 51-56. PMID: 21175347
See how others have used Hypericin (CAS 548-04-9). Click on the entry to view the PubMed entry .
PMID: # 17609769 Mikes, J. et al. 2007. Photochem. Photobiol. Sci. 6: 758-766.
PMID: # 15556948 Rajendra Kumar, P. et al. 2005. J. Biol. Chem. 280: 8553-8563.
PMID: # 15611092 Taniguchi, S. et al. 2005. J. Biol. Chem. 280: 7614-7623.
PMID: # 12052862 Benkoussa, M. et al. 2002. Mol. Cell. Biol. 22: 4522-4534.
PMID: # 10085120 Assefa, Z. et al. 1999. J. Biol. Chem. 274: 8788-8796.
PMID: # 31704507 Photodiagnosis Photodyn Ther. 101588.
PMID: # 32472704 Photochem. Photobiol.
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