Molecular structure of Hypaconitine, CAS Number: 6900-87-4
Hypaconitine (CAS 6900-87-4)
Application:
Hypaconitine is a diterpene alkaloid
CAS Number:
6900-87-4
Purity:
≥90%
Molecular Weight:
615.71
Molecular Formula:
C33H45NO10
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hypaconitine is a diterpene alkaloid extracted from the dried root of Aconitum napellus L., Ranunculaceae and other aconites (common names include monkswood, wolfbane). Hypaconitine is responsible for the neuromuscular blocking action of the aconite root.
Hypaconitine (CAS 6900-87-4) References
- Alkaloidal constituents from Aconitum jaluense. | Shim, SH., et al. 2003. Arch Pharm Res. 26: 709-15. PMID: 14560917
- Effect of hypaconitine combined with liquiritin on the expression of calmodulin and connexin43 in rat cardiac muscle in vivo. | Yi, M., et al. 2012. J Pharm Pharmacol. 64: 1654-8. PMID: 23058053
- Blocking effects of hypaconitine and aconitine on nerve action potentials in phrenic nerve-diaphragm muscles of mice. | Muroi, M., et al. 1990. Neuropharmacology. 29: 567-72. PMID: 2385329
- Hypaconitine-induced QT prolongation mediated through inhibition of KCNH2 (hERG) potassium channels in conscious dogs. | Xie, S., et al. 2015. J Ethnopharmacol. 166: 375-9. PMID: 25800797
- Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses adhesion, migration, and invasion of lung cancer A549 cells. | Feng, HT., et al. 2017. Chin J Nat Med. 15: 427-435. PMID: 28629532
- Circadian Cyp3a11 metabolism contributes to chronotoxicity of hypaconitine in mice. | Lin, Y., et al. 2019. Chem Biol Interact. 308: 288-293. PMID: 31150629
- The mechanism underlying hypaconitine-mediated alleviation of pancreatitis-associated lung injury through up-regulating aquaporin-1/TNF-α. | Gao, J., et al. 2020. Turk J Gastroenterol. 31: 790-798. PMID: 33361042
- Mechanism of action of a diterpene alkaloid hypaconitine on cytotoxicity and inhibitory effect of BAPTA-AM in HCN-2 neuronal cells. | Hsu, SS., et al. 2021. Clin Exp Pharmacol Physiol. 48: 801-810. PMID: 33609056
- Cardioprotective Effects of Aconite in Isoproterenol-Induced Myocardial Infarction in Rats. | Xing, Z., et al. 2022. Oxid Med Cell Longev. 2022: 1090893. PMID: 36600948
- Comprehensive insight into the pharmacology, pharmacokinetics, toxicity, detoxification and extraction of hypaconitine from Aconitum plants. | Xiang, G., et al. 2024. J Ethnopharmacol. 321: 117505. PMID: 38016573
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hypaconitine, 10 mg | sc-205717 | 10 mg | $135.00 | |||
Hypaconitine, 25 mg | sc-205717A | 25 mg | $320.00 |