Molecular structure of Hyocholic Acid
Hyocholic Acid (CAS 547-75-1)
See product citations (6)
Alternate Names:
5β-Cholanic acid-3α, 6α, 7α-triol; λ-Muricholic acid
Application:
Hyocholic Acid is a biliary acid found in human urine
CAS Number:
547-75-1
Purity:
≥98%
Molecular Weight:
408.57
Molecular Formula:
C24H40O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Hyocholic acid is a biliary acid found in human urine. Hyocholic acid works by inhibiting the enzyme ATP-citrate lyase, which is responsible for the conversion of citrate to acetyl-CoA. By inhibiting this enzyme, Hyocholic acid prevents the conversion of carbohydrates into fat, thus reducing fat storage. Additionally, Hyocholic acid may act to increase the activity of the enzyme adenosine monophosphate-activated protein kinase (AMPK).
Hyocholic Acid (CAS 547-75-1) References
- ELISA determination of serum hyocholic acid concentrations in humans and their possible clinical significance. | Kano, M., et al. 1999. Hepatogastroenterology. 46: 983-4. PMID: 10370651
- Formation of hyodeoxycholic acid from muricholic acid and hyocholic acid by an unidentified gram-positive rod termed HDCA-1 isolated from rat intestinal microflora. | Eyssen, HJ., et al. 1999. Appl Environ Microbiol. 65: 3158-63. PMID: 10388717
- EFFECT OF HYOCHOLIC ACID ON CHOLESTEROL AND BILE ACID METABOLISM IN THE MOUSE. | BEHER, WT., et al. 1964. Proc Soc Exp Biol Med. 116: 442-5. PMID: 14193369
- The porcine taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21) gene: evolution by gene duplication and gene conversion. | Lundell, K. 2004. Biochem J. 378: 1053-8. PMID: 14641109
- Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21). | Lundell, K. and Wikvall, K. 2003. Biochim Biophys Acta. 1634: 86-96. PMID: 14643796
- Effect of hyocholic acid on the prevention and dissolution of biliary cholesterol crystals in mice. | Dusserre, JP., et al. 1988. Can J Physiol Pharmacol. 66: 1028-34. PMID: 3179836
- Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. | Zheng, X., et al. 2021. Cell Metab. 33: 791-803.e7. PMID: 33338411
- Hyocholic acid species as novel biomarkers for metabolic disorders. | Zheng, X., et al. 2021. Nat Commun. 12: 1487. PMID: 33674561
- Hyocholic acid and glycemic regulation: comments on 'Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism'. | Jia, W., et al. 2021. J Mol Cell Biol. 13: 460-462. PMID: 33930169
- Effect of Weaning at 21 Days of Age on the Content of Bile Acids in Chyme of Cecum. | Zhang, Y., et al. 2022. Animals (Basel). 12: PMID: 36009728
- Decreased Hyocholic Acid and Lysophosphatidylcholine Induce Elevated Blood Glucose in a Transgenic Porcine Model of Metabolic Disease. | Xu, J., et al. 2022. Metabolites. 12: PMID: 36557202
- Medium chain fatty acid supplementation improves animal metabolic and immune status during the transition period: A study on dairy cattle. | Wang, Z., et al. 2023. Front Immunol. 14: 1018867. PMID: 36776875
- Bile Acid Alterations Characterize the Early Onset and Progression of Nonalcoholic Fatty Liver Disease in Young Mice Fed with High Fat and Fructose Diet. | Xiang, W., et al. 2023. Mol Nutr Food Res. e2200636. PMID: 36938649
- Gas-liquid chromatography of hyocholic acid. | Mott, GE., et al. 1971. J Lipid Res. 12: 117-9. PMID: 5542697
- Hydrophilic bile acids: prevention and dissolution experiments in two animal models of cholesterol cholelithiasis. | Cohen, BI., et al. 1995. Lipids. 30: 855-61. PMID: 8577230
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hyocholic Acid, 5 mg | sc-396739 | 5 mg | $305.00 |