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Hydroxyurea (CAS 127-07-1)

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Alternate Names:
Hydroxyurea is also known as N-hydroxy-urea.
Application:
Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis via ribonucleotide reductase inhibition.
CAS Number:
127-07-1
Purity:
≥99%
Molecular Weight:
76.05
Molecular Formula:
CH4N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hydroxyurea is widely used in molecular biology research, primarily for its ability to inhibit ribonucleotide reductase. This inhibition is central to studies focused on DNA synthesis and repair mechanisms, as Hydroxyurea effectively stalls the replication fork, providing a model for analyzing replication stress responses. Additionally, Hydroxyurea is employed in studies examining cell cycle progression, particularly how cells respond to and recover from replication stress. Its role in inducing fetal hemoglobin production also makes it a subject of interest in genetic studies related to hemoglobinopathies. Moreover, research involving Hydroxyurea extends to its effects on the modification of the chromatin structure, which is for understanding gene expression regulation and cellular differentiation processes.


Hydroxyurea (CAS 127-07-1) References

  1. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment.  |  Steinberg, MH., et al. 2003. JAMA. 289: 1645-51. PMID: 12672732
  2. Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea.  |  Rodgers, GP., et al. 1990. N Engl J Med. 322: 1037-45. PMID: 1690857
  3. Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in children.  |  Strouse, JJ., et al. 2008. Pediatrics. 122: 1332-42. PMID: 19047254
  4. Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli.  |  Davies, BW., et al. 2009. Mol Cell. 36: 845-60. PMID: 20005847
  5. Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis.  |  Lu, X., et al. 2010. Cancer Sci. 101: 609-15. PMID: 20028385
  6. How I use hydroxyurea to treat young patients with sickle cell anemia.  |  Ware, RE. 2010. Blood. 115: 5300-11. PMID: 20223921
  7. Hydroxyurea therapy for sickle cell anemia.  |  McGann, PT. and Ware, RE. 2015. Expert Opin Drug Saf. 14: 1749-58. PMID: 26366626
  8. Hydroxyurea-The Good, the Bad and the Ugly.  |  Musiałek, MW. and Rybaczek, D. 2021. Genes (Basel). 12: PMID: 34356112
  9. Advances in the diagnosis and treatment of sickle cell disease.  |  Brandow, AM. and Liem, RI. 2022. J Hematol Oncol. 15: 20. PMID: 35241123
  10. Induction of apoptosis in chronic myelogenous leukemia lymphocytes by hydroxyurea and adriamycin.  |  Anand, S., et al. 1995. Cancer Lett. 88: 101-5. PMID: 7850765
  11. Randomized comparison of busulfan and hydroxyurea in chronic myelogenous leukemia: prolongation of survival by hydroxyurea. The German CML Study Group.  |  Hehlmann, R., et al. 1993. Blood. 82: 398-407. PMID: 8329700
  12. Hydroxyurea for treatment of unresectable and recurrent meningiomas. II. Decrease in the size of meningiomas in patients treated with hydroxyurea.  |  Schrell, UM., et al. 1997. J Neurosurg. 86: 840-4. PMID: 9126900
  13. The apoptosis of HEL cells induced by hydroxyurea.  |  Gui, CY., et al. 1997. Cell Res. 7: 91-7. PMID: 9261566
  14. Treatment of polycythemia vera: the use of hydroxyurea and pipobroman in 292 patients under the age of 65 years.  |  Najean, Y. and Rain, JD. 1997. Blood. 90: 3370-7. PMID: 9345019
  15. Differential effects of hydroxyurea upon deoxyribonucleoside triphosphate pools, analyzed with vaccinia virus ribonucleotide reductase.  |  Hendricks, SP. and Mathews, CK. 1998. J Biol Chem. 273: 29519-23. PMID: 9792659

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hydroxyurea, 5 g

sc-29061
5 g
$76.00

Hydroxyurea, 25 g

sc-29061A
25 g
$255.00