Molecular structure of Hydroxythiohomo Sildenafil, CAS Number: 479073-82-0
Hydroxythiohomo Sildenafil (CAS 479073-82-0)
Alternate Names:
-[2-Ethoxy-5-[[4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidine-7-thione; 4-[[3-(4,7-Dihydro-1-methyl-3-propyl-7-thioxo-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-1-piperazineethanol;
Application:
Hydroxythiohomo Sildenafil is A thio analog of Sildenafil and a potential PDE5 inhibitor.
CAS Number:
479073-82-0
Purity:
≥98%
Molecular Weight:
520.67
Molecular Formula:
C23H32N6O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hydroxythiohomo Sildenafil is a thio analog of Sildenafil (sc-338584) which has been reported to be a PDE5 inhibitor. Sildenafil is a selective inhibitor of type 5 cGMP phosphodiesterase (PDE5), which catalyzes teh hydrolysis of cGMP, an important secondary messenger molecule in a variety of cellular processes. Sildenafil has been reported to enhance angiogenesis in rat models of stroke and also has been reported to be a mild vasodilator. Sildenafil may act to prevent indomethacin-induced small intestinal ulceration formation throuh an NO/cGMP-dependent mechanism.
Hydroxythiohomo Sildenafil (CAS 479073-82-0) References
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- Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles. | Seftel, AD. 2004. Clin Cardiol. 27: I14-19. PMID: 15115191
- The role of sildenafil in the treatment of stroke. | Bednar, MM. 2008. Curr Opin Investig Drugs. 9: 754-9. PMID: 18600581
- Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism. | Kato, N., et al. 2009. Dig Dis Sci. 54: 2346-56. PMID: 19101800
- Single-Laboratory Validation Study of a Method for Screening and Identification of Phosphodiesterase Type 5 Inhibitors in Dietary Ingredients and Supplements Using Liquid Chromatography/Quadrupole-Orbital Ion Trap Mass Spectrometry: First Action 2015.12. | Vaclavik, L., et al. 2016. J AOAC Int. 99: 55-72. PMID: 26846459
- Simultaneous analysis of 31 anti-impotence compounds potentially illegally added to herbal-based dietary supplements by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. | Shi, S., et al. 2020. J Chromatogr B Analyt Technol Biomed Life Sci. 1144: 122077. PMID: 32251992
- Suspected-target and non-targeted screenings of phosphodiesterase 5 inhibitors in herbal remedies using liquid chromatography-quadrupole time-of-flight-mass spectrometry. | Mohd Yusop, AY., et al. 2021. Drug Test Anal. 13: 965-976. PMID: 32441056
- Fluorescence polarisation for high-throughput screening of adulterated food products via phosphodiesterase 5 inhibition assay. | Mohd Yusop, AY., et al. 2021. Drug Test Anal. 13: 953-964. PMID: 32959983
- [Ultra-high performance liquid chromatography-orbitrap high-resolution mass spectrometry for rapid screening and identification of 32 illegally added drugs in slimming and anti-impotence health foods]. | Xu, H., et al. 2022. Se Pu. 40: 531-540. PMID: 35616198
Inhibitor of:
PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hydroxythiohomo Sildenafil, 1 mg | sc-207746 | 1 mg | $388.00 |