Hydroxyprogesterone Antibody (HPRO-1): sc-57196

Hydroxyprogesterone Antibody (HPRO-1) is a mouse monoclonal IgG3 antibody that detects Hydroxyprogesterone protein of non-species reactive by enzyme-linked immunosorbent assay (ELISA). Anti-Hydroxyprogesterone antibody (HPRO-1) is available as a non-conjugated format. Hydroxyprogesterone, also known as 17alpha Hydroxyprogesterone, plays a crucial role as a C-21 steroid hormone, serving as an intermediary in the synthesis of cortisol, which is vital for stress response and metabolic regulation. This hormone is produced during the biosynthesis of glucocorticoids and sex steroids and interacts with various progesterone receptors, influencing reproductive processes and maintaining pregnancy. Hydroxyprogesterone is distinct from Hydroxyprogesterone caproate, a synthetic variant that shares structural similarities with megestrol acetate and medroxyprogesterone acetate. Hydroxyprogesterone is primarily synthesized in the adrenal glands and, to a lesser extent, in the gonads, particularly in the corpus luteum of the ovary. Elevation during the third trimester of pregnancy is largely due to fetal adrenal development, and has been associated with a reduction in the risk of preterm delivery, highlighting significance in maternal and fetal health.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Hydroxyprogesterone Antibody (HPRO-1) References:

1. Functional effects of 17alpha-hydroxyprogesterone caproate (17P) on human myometrial contractility in vitro.  |  Sexton, DJ., et al. 2004. Reprod Biol Endocrinol. 2: 80. PMID: 15585068
2. Estimated effect of 17 alpha-hydroxyprogesterone caproate on preterm birth in the United States.  |  Petrini, JR., et al. 2005. Obstet Gynecol. 105: 267-72. PMID: 15684150
3. 17 hydroxyprogesterone for the prevention of preterm delivery.  |  Meis, PJ. and ,. 2005. Obstet Gynecol. 105: 1128-35. PMID: 15863556
4. Gestational exposure to hydroxyprogesterone caproate suppresses reproductive potential in male rats.  |  Pushpalatha, T., et al. 2005. Naturwissenschaften. 92: 385-8. PMID: 16049688
5. [17alpha-hydroxyprogesterone].  |  Shimizu, Y. 2005. Nihon Rinsho. 63 Suppl 8: 344-6. PMID: 16149525
6. Efficacy and safety of 17alpha-hydroxyprogesterone caproate in hormone replacement therapy.  |  Agostini, R., et al. 2005. Gynecol Endocrinol. 21: 265-7. PMID: 16373245
7. Production and characterization of monoclonal antibodies against 17alpha-hydroxyprogesterone.  |  Chong, H., et al. 2006. Hybridoma (Larchmt). 25: 34-40. PMID: 16475880
8. 17-Hydroxyprogesterone caproate reverses induced vasoconstriction of the fetoplacental arteries by the thromboxane mimetic U46619.  |  Paonessa, DJ., et al. 2006. Am J Obstet Gynecol. 195: 1011-4. PMID: 16846582
9. Newborn screening levels of 17-hydroxyprogesterone in very low birth weight infants and the relationship to chronic lung disease.  |  Pau, DA., et al. 2006. J Pediatr Endocrinol Metab. 19: 1119-24. PMID: 17128559