Hydroxyfasudil Hydrochloride (CAS 155558-32-0)
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Hydroxyfasudil Hydrochloride is used in research focused on the modulation of protein kinases, particularly Rho-associated protein kinase (ROCK). This compound acts as an inhibitor of ROCK, which allows scientists to study the downstream effects of this inhibition on cell motility, contraction, and proliferation. Hydroxyfasudil Hydrochloride is employed in cellular assays to dissect the signaling pathways involved in cytoskeletal rearrangements and to understand the role of ROCK in these dynamic processes. The compound′s influence on actin filament assembly and myosin light chain phosphorylation is another area of investigation, which contributes to the overall understanding of intracellular transport and cellular morphology.
Hydroxyfasudil Hydrochloride (CAS 155558-32-0) References
- Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. | Shimokawa, H., et al. 1999. Cardiovasc Res. 43: 1029-39. PMID: 10615430
- Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. | Takemoto, M., et al. 2002. Circulation. 106: 57-62. PMID: 12093770
- Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae. | Ito, K., et al. 2003. J Physiol. 546: 823-36. PMID: 12563007
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hydroxyfasudil Hydrochloride, 10 mg | sc-202176 | 10 mg | $300.00 |