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Hydroxy Tolbutamide (CAS 5719-85-7)

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Alternate Names:
Hydroxy Tolbutamide is also known as N-(Butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide.
Application:
Hydroxy Tolbutamide is a P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker.
CAS Number:
5719-85-7
Molecular Weight:
286.35
Molecular Formula:
C12H18N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hydroxy Tolbutamide, also known as 4-Hydroxy Tolbutamide, is a metabolite of tolbutamide, which is a first-generation potassium channel blocker. It is formed through the activity of cytochrome P450 enzymes, specifically CYP2C8 and CYP2C9. Belonging to the class of benzenesulfonamides, Hydroxy Tolbutamide is an organic compound characterized by a sulfonamide group linked to a benzene ring. It is considered practically insoluble in water and has a relatively neutral nature. This molecule has been detected in human liver and kidney tissues, as well as in biofluids like urine and blood. Within the cell, it is predominantly located in the cytoplasm. Structurally, Hydroxy Tolbutamide is a urea compound with a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position of 1-butylurea. Its primary role is that of a metabolite. It falls into the categories of sulfonamides, ureas, and benzyl alcohols.


Hydroxy Tolbutamide (CAS 5719-85-7) References

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  3. Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes.  |  Niwa, T., et al. 2005. Biol Pharm Bull. 28: 1805-8. PMID: 16141567
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hydroxy Tolbutamide, 2 mg

sc-218585A
2 mg
$184.00

Hydroxy Tolbutamide, 5 mg

sc-218585
5 mg
$255.00

Hydroxy Tolbutamide, 10 mg

sc-218585B
10 mg
$408.00

Hydroxy Tolbutamide, 25 mg

sc-218585C
25 mg
$893.00

Hydroxy Tolbutamide, 50 mg

sc-218585D
50 mg
$1408.00