Molecular structure of Hydroxy Pioglitazone (M-IV), CAS Number: 146062-44-4
Hydroxy Pioglitazone (M-IV) (CAS 146062-44-4)
Alternate Names:
5-[[4-[2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Application:
Hydroxy Pioglitazone (M-IV) is a pioglitazone metabolite
CAS Number:
146062-44-4
Molecular Weight:
372.44
Molecular Formula:
C19H20N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hydroxy Pioglitazone (M-IV) is a metabolite of the PPARγ agonist pioglitazone (sc-202289) and a member of the classes of thiazolidenedione, pyridine, and aromatic ether compounds. It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy Pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).
Hydroxy Pioglitazone (M-IV) (CAS 146062-44-4) References
- Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone. | Tanis, SP., et al. 1996. J Med Chem. 39: 5053-63. PMID: 8978836
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hydroxy Pioglitazone (M-IV), 500 µg | sc-218584 | 500 µg | $305.00 | |||
Hydroxy Pioglitazone (M-IV), 5 mg | sc-218584A | 5 mg | $1620.00 | |||
Hydroxy Pioglitazone (M-IV), 10 mg | sc-218584B | 10 mg | $2900.00 |