Molecular structure of Hydroxy Itraconazole, CAS Number: 112559-91-8
Hydroxy Itraconazole (CAS 112559-91-8)
Alternate Names:
4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one
Application:
Hydroxy Itraconazole is an active antimycotic metabolite
CAS Number:
112559-91-8
Molecular Weight:
721.63
Molecular Formula:
C35H38Cl2N8O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hydroxy Itraconazole (OH-ITZ) is an active metabolite of itraconazole (sc-205724), an antimycotic compound structurally related to ketoconazole (sc-200496). It has been studied for its potential anticancer activity, particularly against prostate cancer, and as a potential treatment for tropical diseases such as Chagas disease and leishmaniasis. Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections. It has been found in human liver and kidney tissues, and has also been detected in multiple biofluids, such as urine and blood.
Hydroxy Itraconazole (CAS 112559-91-8) References
- Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro. | Odds, FC. and Bossche, HV. 2000. J Antimicrob Chemother. 45: 371-3. PMID: 10702560
- Column-switching chromatographic determination of itraconazole and its metabolite hydroxy-itraconazole in human serum. | Kubalec, P. and Brandsteterová, E. 2001. Pharmazie. 56: 397-400. PMID: 11400556
- A rapid HPLC method with fluorometric detection for determination of plasma itraconazole and hydroxy-itraconazole concentrations in cystic fibrosis children with allergic bronchopulmonary aspergillosis. | Redmann, S. and Charles, BG. 2006. Biomed Chromatogr. 20: 343-8. PMID: 16161186
- Development of a high-throughput method for the determination of itraconazole and its hydroxy metabolite in human plasma, employing automated liquid-liquid extraction based on 96-well format plates and LC/MS/MS. | Kousoulos, C., et al. 2006. Anal Bioanal Chem. 384: 199-207. PMID: 16333603
- Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole. | Mino, Y., et al. 2013. Clin Chim Acta. 415: 128-32. PMID: 23089073
- A simple, sensitive HPLC-PDA method for the quantification of itraconazole and hydroxy itraconazole in human serum: a reference laboratory experience. | Cendejas-Bueno, E., et al. 2013. Diagn Microbiol Infect Dis. 76: 314-20. PMID: 23588004
- Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry. | Liang, X., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1020: 111-9. PMID: 27038403
- Reliable and Easy-To-Use Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Analysis of Fluconazole, Isavuconazole, Itraconazole, Hydroxy-Itraconazole, Posaconazole, and Voriconazole in Human Plasma and Serum. | Müller, C., et al. 2017. Ther Drug Monit. 39: 505-513. PMID: 28742650
- Population in vitro-in vivo pharmacokinetic model of first-pass metabolism: itraconazole and hydroxy-itraconazole. | Abuhelwa, AY., et al. 2018. J Pharmacokinet Pharmacodyn. 45: 181-197. PMID: 29150770
- Simultaneous determination of voriconazole, posaconazole, itraconazole and hydroxy-itraconazole in human plasma using LCMS/MS. | Jenkins, N., et al. 2018. Clin Biochem. 53: 110-115. PMID: 29325818
- Repurposing antifungals: population pharmacokinetics of itraconazole and hydroxy-itraconazole following administration of a nanocrystal formulation. | Jansen, AME., et al. 2023. J Antimicrob Chemother.. PMID: 36935381
- Simultaneous determination of itraconazole, hydroxy-itraconazole and amphotericin B in human plasma by HPLC with photodiode array detection. | Lacroix, C., et al. 1995. Ann Biol Clin (Paris). 53: 293-7. PMID: 7574117
- Itraconazole solution: higher serum drug concentrations and better clinical response rates than the capsule formulation in acquired immunodeficiency syndrome patients with candidosis. | Cartledge, JD., et al. 1997. J Clin Pathol. 50: 477-80. PMID: 9378812
- Determination of itraconazole and hydroxy-itraconazole in sera using high-performance-liquid-chromatography and a bioassay. | Hülsewede, JW., et al. 1995. Zentralbl Bakteriol. 282: 457-64. PMID: 9810671
- Optimisation of itraconazole therapy using target drug concentrations. | Poirier, JM. and Cheymol, G. 1998. Clin Pharmacokinet. 35: 461-73. PMID: 9884817
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hydroxy Itraconazole, 1 mg | sc-211607 | 1 mg | $315.00 | |||
Hydroxy Itraconazole, 1 mg | sc-211607-CW | 1 mg | $500.00 | |||
Hydroxy Itraconazole, 5 mg | sc-211607A | 5 mg | $1475.00 | |||
Hydroxy Itraconazole, 10 mg | sc-211607B | 10 mg | $2530.00 | |||
Hydroxy Itraconazole, 25 mg | sc-211607C | 25 mg | $4399.00 |