Date published: 2026-4-4

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Hydrocortisone (CAS 50-23-7)

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See product citations (6)

Alternate Names:
Cortisol
Application:
Hydrocortisone is a primary glucocorticoid and anti-inflammatory agent
CAS Number:
50-23-7
Purity:
≥98%
Molecular Weight:
362.46
Molecular Formula:
C21H30O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hydrocortisone is the primary glucocorticoid secreted by the adrenal cortex. Hydrocortisone has three times the anti-inflammatory potency of corticosterone but much lower Na+ retention potency.Hydrocortisone plays a role in the regulation of metabolism, electrolyte balance, water balance, and the body′s stress response. It has been utilized in research to investigate the impact of inflammation and stress on cellular processes.


Hydrocortisone (CAS 50-23-7) References

  1. [Metabolic assessment of hydrocortisone replacement therapy in patients with primary adrenocortical insufficiency].  |  Fichna, M., et al. 2011. Przegl Lek. 68: 96-102. PMID: 21751518
  2. Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation.  |  Johannsson, G., et al. 2012. J Clin Endocrinol Metab. 97: 473-81. PMID: 22112807
  3. Daily endogenous cortisol production and hydrocortisone pharmacokinetics in adult horses and neonatal foals.  |  Hart, KA., et al. 2012. Am J Vet Res. 73: 68-75. PMID: 22204290
  4. Subcutaneous hydrocortisone administration for emergency use in adrenal insufficiency.  |  Hahner, S., et al. 2013. Eur J Endocrinol. 169: 147-54. PMID: 23672956
  5. [Utility of challenge test in immediate hypersensitivity to hydrocortisone sodium succinate].  |  Amaya-Mejía, AS., et al. 2014. Rev Alerg Mex. 61: 32-7. PMID: 24913000
  6. C-20 Ketone reduction of hydrocortisone by Fusarium solani and Aspergillus ochraceus.  |  Gandomkar, S., et al. 2014. Biotechnol Lett. 36: 2271-4. PMID: 25048228
  7. Comparison of cortisol exposures and pharmacodynamic adrenal steroid responses to hydrocortisone suspension vs. commercial tablets.  |  Sarafoglou, K., et al. 2015. J Clin Pharmacol. 55: 452-7. PMID: 25385533
  8. Interruptions to supply of high-dose hydrocortisone tablets and the incidence of adrenal crises.  |  Rushworth, RL., et al. 2015. Clin Endocrinol (Oxf). 83: 999-1000. PMID: 26018415
  9. Cationic lipid-conjugated hydrocortisone as selective antitumor agent.  |  Rathore, B., et al. 2016. Eur J Med Chem. 108: 309-321. PMID: 26695732
  10. Hydrocortisone in the management of acute hypoadrenocorticism in dogs: a retrospective series of 30 cases.  |  Gunn, E., et al. 2016. J Small Anim Pract. 57: 227-33. PMID: 27101159
  11. Achieving a physiological cortisol profile with once-daily dual-release hydrocortisone: a pharmacokinetic study.  |  Johannsson, G., et al. 2016. Eur J Endocrinol. 175: 85-93. PMID: 27129362
  12. Accuracy of hydrocortisone dose administration via nasogastric tube.  |  Daniel, E., et al. 2019. Clin Endocrinol (Oxf). 90: 66-73. PMID: 30311954
  13. Cortisol Circadian Rhythm and Insulin Resistance in Muscle: Effect of Dosing and Timing of Hydrocortisone Exposure on Insulin Sensitivity in Synchronized Muscle Cells.  |  Negri, M., et al. 2021. Neuroendocrinology. 111: 1005-1028. PMID: 33130679

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hydrocortisone, 5 g

sc-300810
5 g
$102.00