Date published: 2025-10-18

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Hydrochlorothiazide-13C,d2 (CAS 1190006-03-1)

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Alternate Names:
6-chloro-3,3-dideuterio-1,1-dioxo-2,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
Application:
Hydrochlorothiazide-13C,d2 is a labeled inhibitor of carbonic anhydrase
CAS Number:
1190006-03-1
Molecular Weight:
300.75
Molecular Formula:
(13C)C6H6D2ClN3O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hydrochlorothiazide-13C,d2 is a labeled form of hydrochlorothiazide, a diuretic compound that inhibits the reabsorption of sodium and chloride in the distal convoluted tubules of the kidneys. Hydrochlorothiazide-13c,D2 acts by blocking the sodium-chloride symporter, leading to increased excretion of sodium, chloride, and water. By promoting diuresis, hydrochlorothiazide-13C,d2 can be used to study the dynamics of electrolyte and fluid balance in experimental models. Its mechanism of action involves interfering with the normal reabsorption process in the kidneys, ultimately leading to increased urinary excretion of sodium and chloride. This labeled form of hydrochlorothiazide can be utilized to track the movement and metabolism of the compound within biological systems, providing insights into its pharmacokinetics and distribution. Hydrochlorothiazide-13C,d2 served for investigating the mechanisms of diuresis and renal function in experimental applications.


Hydrochlorothiazide-13C,d2 (CAS 1190006-03-1) References

  1. High-throughput quantification of 8 antihypertensive drugs and active metabolites in human plasma using UPLC-MS/MS.  |  van der Nagel, BCH., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1060: 367-373. PMID: 28666228
  2. Fast and sensitive LC-MS/MS method for the simultaneous determination of lisinopril and hydrochlorothiazide in human plasma.  |  Shah, JV., et al. 2017. J Pharm Anal. 7: 163-169. PMID: 29404033
  3. Simultaneous quantification of amiloride and hydrochlorothiazide in human plasma by liquid chromatography-tandem mass spectrometry.  |  Shah, JV., et al. 2017. J Pharm Anal. 7: 288-296. PMID: 29404051
  4. Application of an LC-MS/MS method for the analysis of amlodipine, valsartan and hydrochlorothiazide in polypill for a bioequivalence study.  |  Shah, JV., et al. 2017. J Pharm Anal. 7: 309-316. PMID: 29404054
  5. Pharmacokinetic comparison between a fixed-dose combination of fimasartan/amlodipine/hydrochlorothiazide 60/10/25 mg and a corresponding loose combination of fimasartan/amlodipine 60/25 mg and hydrochlorothiazide 25 mg in healthy subjects.  |  Jung, J., et al. 2021. Transl Clin Pharmacol. 29: 53-64. PMID: 33855001

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hydrochlorothiazide-13C,d2, 2.5 mg

sc-280791
2.5 mg
$350.00

Hydrochlorothiazide-13C,d2, 10 mg

sc-280791A
10 mg
$1180.00

Hydrochlorothiazide-13C,d2, 25 mg

sc-280791B
25 mg
$2450.00