Hyaluronidase (CAS 37259-53-3)
See product citations (4)
Alternate Names:
Hyaluronidase is also known as Hyaluronate Lyase.
Application:
Hyaluronidase is an enzyme that specifically cleaves hyaluronic acid, and can be used as media for the isolation and purifying of single cells.
CAS Number:
37259-53-3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Hyaluronidase is an enzyme widely present in nature. In addition to humans, it is found in the organs and bodily fluid of nematodes, leeches, snakes, scorpions, bees, spiders, wasps, hornets, caterpillars, lizards, and fish. Hyaluronidase is also present in the secretions of virus, bacteriophage, fungi and bacteria. It is used in the preparation of DMEM/F-12 media. Hyaluronidase is a component of digestion solution for the derivation of germline stem cells in certain types of cancer. It cleaves hyaluronic acid at the β-D-GalNAc-(1→4)-β-D-GlcA bond, yielding 3-(4-deoxy-β-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine tetra- and hexasaccharides.
Hyaluronidase (CAS 37259-53-3) References
- The six hyaluronidase-like genes in the human and mouse genomes. | Csoka, AB., et al. 2001. Matrix Biol. 20: 499-508. PMID: 11731267
- Hyaluronidase inhibitors: a biological and therapeutic perspective. | Girish, KS., et al. 2009. Curr Med Chem. 16: 2261-88. PMID: 19519390
- Binding of trastuzumab to ErbB2 is inhibited by a high pericellular density of hyaluronan. | Váradi, T., et al. 2012. J Histochem Cytochem. 60: 567-75. PMID: 22562558
- The role of hyaluronidase in the treatment of complications from hyaluronic acid dermal fillers. | Cavallini, M., et al. 2013. Aesthet Surg J. 33: 1167-74. PMID: 24197934
- CD44v8-10 is a cancer-specific marker for gastric cancer stem cells. | Lau, WM., et al. 2014. Cancer Res. 74: 2630-41. PMID: 24618343
- Use of hyaluronidase for pharmacokinetic increase in bioavailability of intracutaneously applied substances. | Wohlrab, J., et al. 2014. Skin Pharmacol Physiol. 27: 276-82. PMID: 24944044
- Property and current clinical applications of mammal hyaluronidase. | Lv, SH., et al. 2015. Eur Rev Med Pharmacol Sci. 19: 3968-76. PMID: 26531287
- Isolation, characterization, and localization of glycosaminoglycans in rabbit bone marrow. | Oguri, K., et al. 1987. Blood. 70: 501-10. PMID: 3111561
- Production of a novel recombinant brown spider hyaluronidase in baculovirus-infected insect cells. | De-Bona, E., et al. 2021. Enzyme Microb Technol. 146: 109759. PMID: 33812558
- Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts. | Schmaus, A., et al. 2022. Matrix Biol. 109: 173-191. PMID: 35405271
- Novel hyaluronidase from streptomyces. | Ohya, T. and Kaneko, Y. 1970. Biochim Biophys Acta. 198: 607-9. PMID: 5436162
- Exploration of the action pattern of Streptomyces hyaluronate lyase using high-resolution capillary electrophoresis. | Park, Y., et al. 1997. Biochim Biophys Acta. 1337: 217-26. PMID: 9048898
- Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses. | Menzel, EJ. and Farr, C. 1998. Cancer Lett. 131: 3-11. PMID: 9839614
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hyaluronidase, 1 ampule | sc-360249 | 1 ampule | $227.00 | |||
Hyaluronidase, 5 vial | sc-360249A | 5 vial | $865.00 |