Hyaluronidase CAS: 37259-53-3
An enzyme that specifically cleaves hyaluronic acid.

Hyaluronidase (CAS 37259-53-3)

Hyaluronidase | CAS 37259-53-3 is rated 4.5 out of 5 by 2.
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Alternate Names: Hyaluronate Lyase
Application: Hyaluronidase is an enzyme that specifically cleaves hyaluronic acid
CAS Number: 37259-53-3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Hyaluronate lyase cleaves hyaluronic acid at the β-D-GalNAc-(1→4)-β-D-GlcA bond, yielding 3-(4-deoxy-β-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine tetra- and hexasaccharides. Unlike other hyaluronidases, this enzyme is specific for hyaluronic acid and is inactive with Chondroitin and Chondroitn sulfate (sc-203888).

One unit will cause a change in A600 nm of 0.330 per minute at pH 5.7 at 37° C during a 45 minute assay.

Formulation :
One ampule contains 300 units
Appearance :
lyophilized powder
Physical State :
Solid
Derived From :
Streptomyces hyalurolyticus
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3

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Certificate of Analysis

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Hyaluronidase (CAS 37259-53-3)  Product Citations

See how others have used Hyaluronidase (CAS 37259-53-3). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 24446084  Mima, K. et al. 2014. The British journal of surgery. 101: 269-76.

PMID: # 23391595  Lindwall, C. et al. 2013. Brain research. 1503: 62-77.

PMID: # 32442025  Am. J. Physiol. Heart Circ. Physiol.

Citations 1 to 3 of 3 total

How should the enzyme be reconstituted for long-term storage and at these conditions how long is the enzyme stable for?

Asked by: harding
Thank you for your question. The product has buffer present (it is lyophilized from 0.5 mM Tris buffer at pH 7), it is soluble in 1 mL of water and should be stored refrigerated; do not freeze since it is not known what effect freeze/thawing would have on the solutions. Unfortunately we do not have an estimate of stability time for refrigerated enzyme solutions.
Answered by: Tech Service
Date published: 2019-04-17
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Rated 4 out of 5 by from works as expected This hyaluronidase was cheaper and more readily available than options offered by some other companies, with same apparent enzyme activity. Documentation was not included, but technical support was very helpful in determining resuspension and storage methods.
Date published: 2017-11-06
Rated 5 out of 5 by from Yamaguchi et al Yamaguchi et al. (PubMed ID 26296532) used hyaluronidase to inhibit the activity of hyaluronic acid by cleaving. -SCBT Publication Review
Date published: 2015-04-01
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