HYAL4 Antibody (A-7): sc-377369
- HYAL4 Antibody (A-7) is a mouse monoclonal IgG2b κ HYAL4 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 162-206 mapping within an internal region of HYAL4 of mouse origin
- HYAL4 Antibody (A-7) is recommended for detection of HYAL4 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-HYAL4 Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HYAL4 Antibody (A-7) for WB applications. These reagents are now offered in bundles with HYAL4 Antibody (A-7) (see ordering information below).
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HYAL4 Antibody (A-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects HYAL4 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HYAL4 (A-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HYAL4 is a member of the hyaluronidase family, which plays a critical role in the degradation of hyaluronic acid, a vital component of the extracellular matrix that maintains tissue hydration and supports cellular functions such as proliferation and differentiation. HYAL4′s ability to hydrolyze hyaluronic acid is particularly important in physiological processes, including tissue repair and inflammation, as well as in pathological conditions like cancer progression, where HYAL4 may facilitate tumor metastasis by altering the tumor microenvironment. Notably, HYAL4 is differentially expressed in tissues such as the placenta and skeletal muscle, and contains an N-glycosylation site that is essential for enzymatic activity and stability. Additionally, HYAL4 may interact with other hyaluronidases, such as HYALP1 and HYAL5, as well as Ph-20, forming complexes that could enhance functional capabilities in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HYAL4 Antibody (A-7) References:
- Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. | Csóka, AB., et al. 1999. Genomics. 60: 356-61. PMID: 10493834
- Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species. | Fiszer-Szafarz, B., et al. 2000. J Biochem Biophys Methods. 45: 103-16. PMID: 10989127
- The six hyaluronidase-like genes in the human and mouse genomes. | Csoka, AB., et al. 2001. Matrix Biol. 20: 499-508. PMID: 11731267
- Hyaluronidases and CD44 undergo differential modulation during chondrogenesis. | Nicoll, SB., et al. 2002. Biochem Biophys Res Commun. 292: 819-25. PMID: 11944887
- Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass. | Kim, E., et al. 2005. Proc Natl Acad Sci U S A. 102: 18028-33. PMID: 16330764
- Inhibition of hyaluronan hydrolysis catalysed by hyaluronidase at high substrate concentration and low ionic strength. | Astériou, T., et al. 2006. Matrix Biol. 25: 166-74. PMID: 16380245
- Hypoxia-induced alterations in hyaluronan and hyaluronidase. | Gao, F., et al. 2005. Adv Exp Med Biol. 566: 249-56. PMID: 16594159
- Interfacial behaviour of bovine testis hyaluronidase. | Belem-Gonçalves, S., et al. 2006. Biochem J. 398: 569-76. PMID: 16771711
- A hyaluronidase supercatalyst for the enzymatic polymerization to synthesize glycosaminoglycans. | Kobayashi, S., et al. 2006. Chemistry. 12: 5962-71. PMID: 16807948
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HYAL4 Antibody (A-7) | sc-377369 | 200 µg/ml | $322.00 | |||
HYAL4 Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-523299 | 200 µg Ab, 40 µg BP | $361.00 | |||
HYAL4 Antibody (A-7): m-IgG2b BP-HRP Bundle | sc-549103 | 200 µg Ab; 10 µg BP | $361.00 | |||
HYAL4 Antibody (A-7) AC | sc-377369 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HYAL4 Antibody (A-7) HRP | sc-377369 HRP | 200 µg/ml | $322.00 | |||
HYAL4 Antibody (A-7) FITC | sc-377369 FITC | 200 µg/ml | $336.00 | |||
HYAL4 Antibody (A-7) PE | sc-377369 PE | 200 µg/ml | $349.00 | |||
HYAL4 Antibody (A-7) Alexa Fluor® 488 | sc-377369 AF488 | 200 µg/ml | $364.00 | |||
HYAL4 Antibody (A-7) Alexa Fluor® 546 | sc-377369 AF546 | 200 µg/ml | $364.00 | |||
HYAL4 Antibody (A-7) Alexa Fluor® 594 | sc-377369 AF594 | 200 µg/ml | $364.00 | |||
HYAL4 Antibody (A-7) Alexa Fluor® 647 | sc-377369 AF647 | 200 µg/ml | $364.00 | |||
HYAL4 Antibody (A-7) Alexa Fluor® 680 | sc-377369 AF680 | 200 µg/ml | $364.00 | |||
HYAL4 Antibody (A-7) Alexa Fluor® 790 | sc-377369 AF790 | 200 µg/ml | $364.00 |