human thyroid extract: sc-363782
- 500 µg protein in 200 µl SDS-PAGE Western blotting buffer
- Western blotting positive control
- recommended use is 50 µg (20 µl) per lane
- extracts should be stored at -20°C and repeated freezing and thawing should be minimized
- sample vial should be placed at 95° C for up to 5 minutes, once prior to use
- Not available in Germany.
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Human thyroid extract, derived from thyroid tissue, is instrumental in research pertaining to thyroid function and regulation. This extract contains a multitude of biologically active molecules, including thyroid hormones (such as thyroxine and triiodothyronine), thyroglobulin, and various thyroid-specific enzymes. Mechanistically, human thyroid extract has been extensively utilized to investigate thyroid hormone synthesis, secretion, and metabolism, as well as the regulation of thyroid hormone receptors and signaling pathways. Researchers employ this extract to study thyroid disorders, including hypothyroidism, hyperthyroidism, and thyroid cancer, by examining the effects of different hormonal stimuli or environmental factors on thyroid function. Furthermore, human thyroid extract serves as a valuable tool in cell culture experiments aimed at recapitulating the thyroid microenvironment and elucidating the impact of thyroid-derived factors on cellular processes such as proliferation, differentiation, and apoptosis. Studies utilizing human thyroid extract contribute to our understanding of thyroid biology and pathology, providing insights into the molecular mechanisms underlying thyroid function and dysfunction. Overall, human thyroid extract plays a critical role in advancing research related to thyroid physiology and pathology, offering valuable avenues for the development of diagnostic tools.
human thyroid extract References:
- Recovery of thyroid antibodies from human thyroid preparations sensitized in vitro. | MILGROM, F., et al. 1962. Nature. 195: 717-8. PMID: 14473877
- Thyroglobulin may affect telomerase activity in thyroid follicular cells. | Nagasaka, A., et al. 2009. J Enzyme Inhib Med Chem. 24: 524-30. PMID: 18830915
- Initial characterization of C16orf89, a novel thyroid-specific gene. | Afink, GB., et al. 2010. Thyroid. 20: 811-21. PMID: 20578903
- Generation of recombinant, enzymatically active human thyroid peroxidase and its recognition by antibodies in the sera of patients with Hashimoto′s thyroiditis. | Kaufman, KD., et al. 1989. J Clin Invest. 84: 394-403. PMID: 2474568
- Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells. | Crutzen, R., et al. 2016. Pflugers Arch. 468: 573-91. PMID: 26582426
- Glycosylation of human thyroglobulin and characterization by lectin affinity electrophoresis. | Hanham, CA., et al. 1986. Biochim Biophys Acta. 884: 158-65. PMID: 3094587
- Effects of long-acting thyroid stimulator (LATS) and LATS protector on human thyroid adenyl cyclase activity. | Kendall-Taylor, P. 1973. Br Med J. 3: 72-5. PMID: 4740444
- Studies on thyroid proteins. VI. Immunochemical studies on the 4S and 7S tissue-specific thyroid proteins. | Mates, GP. and Shulman, S. 1969. Immunochemistry. 6: 35-42. PMID: 4974992
- Cloning of four DNA fragments complementary to human thyroglobulin messenger RNA. | Bergε-Lefranc, JL., et al. 1981. Eur J Biochem. 120: 1-7. PMID: 6171425
- A possible role for calmodulin in human thyroid cell metabolism. | Ollis, CA., et al. 1983. J Endocrinol. 99: 251-60. PMID: 6317784
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
human thyroid extract | sc-363782 | 500 µg/200 µl | $118.00 |