human stomach extract: sc-363780

Human stomach extract, derived from gastric tissue, is a valuable research tool extensively utilized to investigate the complex mechanisms underlying gastric physiology and pathophysiology. This extract contains a complex mixture of bioactive molecules, including digestive enzymes, mucins, hormones (such as gastrin and ghrelin), and growth factors, reflecting the diverse functions of the stomach in digestion, nutrient absorption, and signaling. Mechanistically, human stomach extract has been employed to study gastric acid secretion, mucosal barrier integrity, gastric motility, and the regulation of appetite and satiety. Researchers utilize this extract to explore the role of gastric factors in gastrointestinal diseases such as gastritis, peptic ulcer disease, and gastric cancer, as well as metabolic disorders related to appetite dysregulation and obesity. Additionally, human stomach extract serves as a crucial component in cell culture models aimed at mimicking the gastric microenvironment and assessing the effects of endogenous gastric factors on epithelial cell function, mucosal defense mechanisms, and inflammatory responses within the stomach. Studies utilizing human stomach extract contribute to our understanding of gastric physiology and pathology, providing insights into the molecular mechanisms governing gastrointestinal health and disease.

human stomach extract References:

1. Ghrelin is a growth-hormone-releasing acylated peptide from stomach.  |  Kojima, M., et al. 1999. Nature. 402: 656-60. PMID: 10604470
2. Synthesis and localization of the mucin-associated TFF-peptides in the human uterus.  |  Wiede, A., et al. 2001. Cell Tissue Res. 303: 109-15. PMID: 11235998