human smooth muscle extract: sc-363778

Human smooth muscle extract, derived from smooth muscle tissue, plays a crucial role in understanding the physiological functions and pathological conditions associated with smooth muscle cells. Smooth muscle cells are integral components of various organ systems, including the gastrointestinal tract, blood vessels, and respiratory airways, where they regulate processes such as peristalsis, vasomotor tone, and airway constriction. Mechanistically, human smooth muscle extract provides researchers with a valuable tool to investigate the signaling pathways, contractile machinery, and regulatory mechanisms underlying smooth muscle function. Studies utilizing this extract have explaind the role of calcium-dependent and independent signaling pathways, G-protein coupled receptors, and ion channels in modulating smooth muscle contraction and relaxation. Additionally, human smooth muscle extract has been employed to explore the pathophysiology of smooth muscle-related disorders, including gastrointestinal motility disorders, hypertension, and asthma. By studying the effects of various pharmacological agents, hormones, and growth factors on smooth muscle function using this extract, researchers can identify potential targets and develop novel treatments for smooth muscle-related diseases. Overall, human smooth muscle extract serves as a valuable research tool for unraveling the complexities of smooth muscle physiology and pathology.

human smooth muscle extract References:

1. HLA-D region alpha-chain monoclonal antibodies: cross-reaction between an anti-DP alpha-chain antibody and smooth muscle.  |  Thomas, A., et al. 1988. J Pathol. 154: 353-63. PMID: 2455029