Human Platelet Extract: sc-363773

Human platelet extract is a rich source of bioactive molecules derived from human platelets, which play a crucial role in hemostasis, wound healing, and tissue regeneration. Platelets contain a plethora of growth factors, cytokines, and chemokines stored in their alpha granules, including platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF). Upon activation, platelets release these factors, initiating cascades of cellular events that promote tissue repair and regeneration. Researchers utilize human platelet extract in various research applications, particularly in studies focusing on wound healing, tissue engineering, and regenerative medicine. The bioactive components present in the extract stimulate cell proliferation, migration, and differentiation, accelerating the healing process and enhancing tissue regeneration. Additionally, human platelet extract has been investigated for its potential applications in promoting tissue repair in various clinical settings, including chronic wounds, burns, and surgical procedures. Furthermore, researchers explore the mechanisms underlying the effects of platelet-derived factors on cellular behavior, providing insights into the molecular pathways involved in tissue regeneration and repair. Overall, human platelet extract serves as a valuable tool in biomedical research, offering potential applications in tissue engineering and regenerative medicine.

Human Platelet Extract References:

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2. Intracellular enzymes of collagen biosynthesis in human platelets.  |  Anttinen, H., et al. 1977. Blood. 50: 29-37. PMID: 194639
3. Human platelets contain brain-derived neurotrophic factor.  |  Yamamoto, H. and Gurney, ME. 1990. J Neurosci. 10: 3469-78. PMID: 2230938
4. Identification of polyphosphoinositide-specific phospholipase C and its resolution from phosphoinositide-specific phospholipase C from human platelet extract.  |  Manne, V. 1987. Oncogene. 2: 49-54. PMID: 2830583
5. Efficacy and Tolerability of Topical Platelet Exosomes for Skin Rejuvenation: Six-Week Results.  |  Proffer, SL., et al. 2022. Aesthet Surg J. 42: 1185-1193. PMID: 35689936
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8. Antiheparin activity of human serum and platelet factor 4.  |  Sear, CH. and Poller, L. 1973. Thromb Diath Haemorrh. 30: 93-105. PMID: 4806356
9. Electron microscopy of human platelet aggregates formed in vitro with and without fibrin production.  |  Warren, BA. and Davey, MG. 1970. Angiologica. 7: 84-103. PMID: 5462027
10. Cellular transformation by coordinated action of three peptide growth factors from human platelets.  |  Assoian, RK., et al. Nature. 309: 804-6. PMID: 6330562
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12. Purification and properties of a human platelet inositol 1,4,5-trisphosphate 3-kinase.  |  Lin, A., et al. 1993. Arch Biochem Biophys. 303: 412-20. PMID: 8390223
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