human bone marrow extract: sc-363752
- 500 µg protein in 200 µl SDS-PAGE Western blotting buffer
- Western blotting positive control
- recommended use is 50 µg (20 µl) per lane
- extracts should be stored at -20°C and repeated freezing and thawing should be minimized
- sample vial should be placed at 95° C for up to 5 minutes, once prior to use
- Not available in Germany.
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Human bone marrow extract is derived from the soft, spongy tissue located inside bones, known as bone marrow, which is a crucial site for hematopoiesisthe process of forming blood cells. This extract is rich in a diverse array of cellular components, including stem cells, hematopoietic cells, and various growth factors that are vital for the generation of blood cells and immune function. The extraction process involves aspirating the marrow from bones, typically the pelvis or sternum, followed by a series of filtration and centrifugation steps designed to isolate specific proteins and cellular elements. In research, human bone marrow extract is extensively used to study the complex processes of hematopoiesis and immune cell generation under various experimental conditions. It provides a critical tool for understanding the biology of stem cells and their niche, including how they differentiate into various blood cell types. Furthermore, this extract has been pivotal in exploring the signaling mechanisms and the microenvironment of the marrow that support the maintenance and proliferation of stem cells. By studying these interactions, researchers can gain insights into the fundamental aspects of cellular biology and the underlying mechanisms that regulate cell function and development within the bone marrow. This knowledge is crucial for advancing the study of hematological health and disease.
human bone marrow extract References:
- Human Induced Pluripotent Stem Cell-Derived Sensory Neurons for Fate Commitment of Bone Marrow Stromal Cell-Derived Schwann Cells. | Cai, S., et al. 2018. Methods Mol Biol. 1739: 149-160. PMID: 29546706
- 5-methyltetrahydrofolate homocysteine cobalamin methyltransferase in human bone marrow and its relationship to pernicious anemia. | Taylor, RT., et al. 1974. Arch Biochem Biophys. 165: 787-95. PMID: 4441104
- Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides from bone marrow, plasma and peripheral blood neutrophils. | Nakazato, M., et al. 1995. Biochem Biophys Res Commun. 211: 1053-62. PMID: 7598692
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
human bone marrow extract | sc-363752 | 500 µg/200 µl | $120.00 |