HUGT2 Antibody (G-7): sc-515421

HUGT2 Antibody (G-7) is a mouse monoclonal IgM antibody that detects HUGT2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HUGT2 antibody (G-7) is available as the non-conjugated form. HUGT2, also known as UGCGL2 (UDP-glucose ceramide glucosyltransferase-like 2) or UGT2 (UDP-glucose: glycoprotein glucosyltransferase 2), is a 1,516 amino acid protein predominantly expressed in the kidney, pancreas, heart, and skeletal muscle. HUGT2 is crucially located in the lumen of the endoplasmic reticulum and the ER-Golgi intermediate compartment, where HUGT2 plays a vital role in the quality control of glycoproteins. HUGT2 functions by targeting unfolded glycoproteins for glucosylation in a calcium-dependent manner, although HUGT2 can utilize manganese in the absence of calcium. This enzymatic process is essential for ensuring that only properly folded proteins are transported to their final destinations, thereby maintaining cellular homeostasis. Notably, alterations in HUGT2 expression have been observed in patients with type 2 diabetes, indicating potential defects in their endoplasmic reticulum glycoprotein quality control mechanisms. HUGT2′s ability to attach single glucose residues to improperly folded glycoproteins underscores HUGT2′s importance in carbohydrate processing and cellular function, making HUGT2 (G-7) antibody a valuable tool for researchers studying glycoprotein quality control and related metabolic disorders.

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HUGT2 Antibody (G-7) References:

1. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity.  |  Arnold, SM., et al. 2000. Biochemistry. 39: 2149-63. PMID: 10694380
2. The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain.  |  Arnold, SM. and Kaufman, RJ. 2003. J Biol Chem. 278: 43320-8. PMID: 12913004
3. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.  |  Marchetti, P., et al. 2007. Diabetologia. 50: 2486-94. PMID: 17906960
4. Identification of UDP glycosyltransferase 3A1 as a UDP N-acetylglucosaminyltransferase.  |  Mackenzie, PI., et al. 2008. J Biol Chem. 283: 36205-10. PMID: 18981171

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HUGT2 Antibody (G-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HUGT2 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HUGT2 Antibody (G-7) Specifications

Alternate Product Name: HUGT2

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 35-50

Epitope Target: HUGT2

Epitope Species: human

Product Reactivity/Detection: HUGT2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HUGT2 Antibody (G-7): P: Blocking Peptide