HTLV-2 gp46 Antibody (73/4.9.8): sc-57874

HTLV-2 gp46 Antibody (73/4.9.8) is a mouse monoclonal IgG1 antibody that detects the HTLV-2 gp46 protein of HTLV-2 origin by western blotting (WB) and immunofluorescence (IF). Anti-HTLV-2 gp46 antibody (73/4.9.8) is available as the non-conjugated format. Human T-lymphotropic virus (HTLV) is a single-stranded RNA retrovirus linked to T-cell leukemia and lymphoma in adults, as well as certain demyelinating diseases. While HTLV-1 is more widely studied due to its association with various diseases, HTLV-2 shares approximately 70% genomic homology with HTLV-1 and has been implicated in cases of myelopathy/tropical spastic paraparesis (HAM/TSP)-like neurological disorders. The HTLV-2 gp46 protein is a critical surface glycoprotein located on the viral envelope, playing a vital role in the host′s immune response to the virus. Notably, HTLV-2 gp46 undergoes post-translational modifications, including glycosylation, which are essential for stability and function. These modifications can influence HTLV-2 gp46′s interactions with host cell receptors and immune components, thereby affecting viral ability to evade the immune system and establish infection. HTLV-2 gp46 also interacts with heat shock cognate protein (HSC 70), a process that may facilitate pore formation in lipid bilayers, leading to membrane fusion or cell death, further underscoring the importance in viral pathogenesis.

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HTLV-2 gp46 Antibody (73/4.9.8) References:

1. HTLV type 1 envelope glycoprotein gp46 evokes necrosis by binding to receptor complex.  |  Sagara, Y., et al. 2000. AIDS Res Hum Retroviruses. 16: 1701-4. PMID: 11080813
2. Chimeric synthetic peptides from the envelope (gp46) and the transmembrane (gp21) glycoproteins for the detection of antibodies to human T-cell leukemia virus type II.  |  Hernández Marin, M., et al. 2001. Biochem Biophys Res Commun. 289: 7-12. PMID: 11708768
3. Epitope mapping of human monoclonal antibodies recognizing conformational epitopes within HTLV type 1 gp46, employing HTLV type 1/2 envelope chimeras.  |  Hadlock, KG., et al. 2002. AIDS Res Hum Retroviruses. 18: 57-70. PMID: 11804557
4. Processing of the HTLV-II envelope precursor glycoprotein gp63 by furin is essential for cell fusion activity.  |  Hasegawa, H., et al. 2002. AIDS Res Hum Retroviruses. 18: 1253-60. PMID: 12487813
5. Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa.  |  Calattini, S., et al. 2005. Retrovirology. 2: 30. PMID: 15882466
6. Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides.  |  Horal, P., et al. 1991. Proc Natl Acad Sci U S A. 88: 5754-8. PMID: 1712105
7. [Production of HTLV-II env protein and its suppressive effect on infection].  |  Kawamura, N. 1995. Hokkaido Igaku Zasshi. 70: 635-47. PMID: 7590608
8. Immunoelectron microscopic study of HTLV-II-producing cells with an anti-envelope gp46 monoclonal antibody.  |  Ohara, N., et al. 1995. Arch Virol. 140: 1291-5. PMID: 7646360
9. Infection and cellular activation by human T-cell leukemia viruses, types I and II.  |  Martin, TC. and Southern, PJ. 1996. Virology. 221: 375-81. PMID: 8661450
10. A source of glycosylated human T-cell lymphotropic virus type 1 envelope protein: expression of gp46 by the vaccinia virus/T7 polymerase system.  |  Arp, J., et al. 1996. J Virol. 70: 7349-59. PMID: 8892853
11. Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46.  |  Hadlock, KG., et al. 1997. J Virol. 71: 5828-40. PMID: 9223472
12. Analysis of functional conservation in the surface and transmembrane glycoprotein subunits of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2.  |  Rosenberg, AR., et al. 1998. J Virol. 72: 7609-14. PMID: 9696862

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HTLV-2 gp46 Antibody (73/4.9.8) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HTLV-2 gp46 Antibody (73/4.9.8) Specifications

Alternate Product Name: HTLV-2 gp46

Product Clone Name: 73/4.9.8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: HTLV-2 gp46

Epitope Species: HTLV-2

Product Reactivity/Detection: HTLV-2 gp46

Species Reactivity/Detection: HTLV-2

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HTLV-2 gp46 Antibody (73/4.9.8): N/A