HSV-2 ICP8 Major DNA binding protein Antibody (4E6): sc-56992

HSV-2 ICP8 Major DNA binding protein Antibody (4E6) is a mouse monoclonal IgG2a antibody that detects HSV-2 ICP8 Major DNA binding protein of Herpes Simplex Virus 2 origin by western blotting (WB) and immunofluorescence (IF). Anti-HSV-2 ICP8 Major DNA binding protein antibody (4E6) is available as the non-conjugated format. The herpes simplex virus (HSV) is a significant pathogen known for causing contagious diseases, with HSV-2 strain primarily associated with genital infections. HSV-2 ICP8 plays a crucial role in the viral life cycle as an essential component for viral genome replication. HSV-2 ICP8 binds to single-stranded DNA, facilitating the formation of a stable double-stranded DNA structure, which is vital for virus replication and host latency establishment. HSV-2 ICP8′s ability to destabilize DNA helices at higher concentrations allows for DNA replication process regulation, making HSV-2 ICP8 a key target for therapeutic interventions aimed at controlling HSV infections. Understanding HSV-2 ICP8 function is important not only for virology research but also for developing strategies to combat herpes simplex virus-related diseases.

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HSV-2 ICP8 Major DNA binding protein Antibody (4E6) References:

1. Photoaffinity labeling of the herpes simplex virus type-1 single-strand DNA-binding protein (ICP8) with oligodeoxyribonucleotides.  |  White, EJ. and Boehmer, PE. 1999. Biochem Biophys Res Commun. 264: 493-7. PMID: 10529391
2. Equilibrium binding of single-stranded DNA with herpes simplex virus type I-coded single-stranded DNA-binding protein, ICP8.  |  Gourves, AS., et al. 2000. J Biol Chem. 275: 10864-9. PMID: 10753882
3. In vitro strand exchange promoted by the herpes simplex virus type-1 single strand DNA-binding protein (ICP8) and DNA helicase-primase.  |  Nimonkar, AV. and Boehmer, PE. 2002. J Biol Chem. 277: 15182-9. PMID: 11832483
4. The herpes simplex virus type-1 single-strand DNA-binding protein (ICP8) promotes strand invasion.  |  Nimonkar, AV. and Boehmer, PE. 2003. J Biol Chem. 278: 9678-82. PMID: 12645567
5. On the mechanism of strand assimilation by the herpes simplex virus type-1 single-strand DNA-binding protein (ICP8).  |  Nimonkar, AV. and Boehmer, PE. 2003. Nucleic Acids Res. 31: 5275-81. PMID: 12954763
6. Catalysis of strand exchange by the HSV-1 UL12 and ICP8 proteins: potent ICP8 recombinase activity is revealed upon resection of dsDNA substrate by nuclease.  |  Reuven, NB., et al. 2004. J Mol Biol. 342: 57-71. PMID: 15313607
7. Visualization of the annealing of complementary single-stranded DNA catalyzed by the herpes simplex virus type 1 ICP8 SSB/recombinase.  |  Makhov, AM. and Griffith, JD. 2006. J Mol Biol. 355: 911-22. PMID: 16343538
8. Establishment of a novel foreign gene delivery system combining an HSV amplicon with an attenuated replication-competent virus, HSV-1 HF10.  |  Zhang, L., et al. 2006. J Virol Methods. 137: 177-83. PMID: 16854473
9. The herpes simplex virus type-1 single-strand DNA-binding protein, ICP8, increases the processivity of the UL9 protein DNA helicase.  |  Boehmer, PE. 1998. J Biol Chem. 273: 2676-83. PMID: 9446572

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSV-2 ICP8 Major DNA binding protein Antibody (4E6) has 3 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSV-2 ICP8 Major DNA binding protein Antibody (4E6) Specifications

Alternate Product Name: HSV-2 ICP8 Major DNA binding protein

Product Clone Name: 4E6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: HSV-2 ICP8 Major DNA binding protein

Epitope Species: herpes simplex virus type 2

Product Reactivity/Detection: ICP8 Major DNA binding protein

Species Reactivity/Detection: Herpes Simplex Virus 2

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for HSV-2 ICP8 Major DNA binding protein Antibody (4E6): N/A