HSV-2 gB Antibody (1.B.44): sc-57857
- HSV-2 gB Antibody (1.B.44) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against HSV (II) infected cells
- recommended for detection of glycoprotein B of Herpes Simplex Virus 2 origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSV-2 gB Antibody (1.B.44). This work is in progress.
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HSV-2 gB Antibody (1.B.44) is a mouse monoclonal IgG1 antibody that detects herpes simplex virus 2 glycoprotein B (gB), with reactivity specific to Herpes Simplex Virus 2, and is suitable for western blotting (WB) and immunofluorescence (IF). Anti-HSV-2 gB antibody (1.B.44) plays a critical role in understanding the structure of gB protein, which is essential for viral entry. HSV-2 gB (1.B.44) monoclonal antibody helps reveal how gB protein exists as a homodimer, a configuration crucial for membrane fusion during viral infection. This dimerization is facilitated by disulfide bonds, which stabilize the protein′s structure and ensure proper functioning. The extracellular domain of HSV-2 gB spans amino acids 23 to 727, while the cytoplasmic domain extends from amino acids 793 to 904, highlighting the importance of structural integrity for viral attachment and entry into host cells. Understanding gB structure is vital, as this knowledge aids in developing therapeutic strategies against herpes simplex virus infections and provides insights into viral pathogenesis mechanisms. HSV-2 gB (1.B.44) antibody serves as an invaluable tool for researchers studying herpes simplex virus infection dynamics and glycoprotein roles in viral entry.
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HSV-2 gB Antibody (1.B.44) References:
- Characterization of cell-cell fusion mediated by herpes simplex virus 2 glycoproteins gB, gD, gH and gL in transfected cells. | Muggeridge, MI. 2000. J Gen Virol. 81: 2017-2027. PMID: 10900041
- Truncation of herpes simplex virus type 2 glycoprotein B increases its cell surface expression and activity in cell-cell fusion, but these properties are unrelated. | Fan, Z., et al. 2002. J Virol. 76: 9271-83. PMID: 12186911
- Immunological properties of a DNA plasmid encoding a chimeric protein of herpes simplex virus type 2 glycoprotein B and glycoprotein D. | Domingo, C., et al. 2003. Vaccine. 21: 3565-74. PMID: 12922084
- N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function. | Cairns, TM., et al. 2007. J Virol. 81: 5102-11. PMID: 17344290
- The efficacy of HSV-2 vaccines based on gD and gB is enhanced by the addition of ICP27. | Bright, H., et al. 2012. Vaccine. 30: 7529-35. PMID: 23103198
- Topical herpes simplex virus 2 (HSV-2) vaccination with human papillomavirus vectors expressing gB/gD ectodomains induces genital-tissue-resident memory CD8+ T cells and reduces genital disease and viral shedding after HSV-2 challenge. | Çuburu, N., et al. 2015. J Virol. 89: 83-96. PMID: 25320297
- Contribution of N-linked glycans on HSV-2 gB to cell-cell fusion and viral entry. | Luo, S., et al. 2015. Virology. 483: 72-82. PMID: 25965797
- Patient-Specific Neutralizing Antibody Responses to Herpes Simplex Virus Are Attributed to Epitopes on gD, gB, or Both and Can Be Type Specific. | Cairns, TM., et al. 2015. J Virol. 89: 9213-31. PMID: 26109729
- Disulfide bonds of herpes simplex virus type 2 glycoprotein gB. | Norais, N., et al. 1996. J Virol. 70: 7379-87. PMID: 8892856
- Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D. | Manning, WC., et al. 1997. J Virol. 71: 7960-2. PMID: 9311887
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSV-2 gB Antibody (1.B.44) | sc-57857 | 100 µg/ml | $322.00 |