HSV-1/2 gB Antibody (H1359): sc-69798
- HSV-1/2 gB Antibody (H1359) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against glycoprotein B of herpesvirus origin
- recommended for detection of glycoprotein B of HSV-1 and HSV-2 origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSV-1/2 gB Antibody (H1359). This work is in progress.
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HSV-1/2 gB Antibody (H1359) is a mouse monoclonal IgG1 antibody that detects glycoprotein B (gB) of HSV-1 and HSV-2 by western blotting (WB) and immunofluorescence (IF). Anti-HSV-1/2 gB antibody (H1359) is essential for studying the role of gB in the viral life cycle, as glycoprotein B is a critical component of the herpes simplex virus envelope that facilitates membrane fusion, a key step in viral entry into host cells. The gB protein exists as a homodimer, which is crucial for its function, and is linked by disulfide bonds, ensuring stability and proper interaction with other viral glycoproteins during the fusion process. The extracellular domain of HSV-1 gB spans amino acids 31 to 730, while the cytoplasmic domain extends from amino acids 796 to 904, and similar structural features are observed in HSV-2 gB. Understanding the structure of gB is vital, as gB not only plays a role in viral entry but also serves as a target for therapeutic interventions and vaccine development. HSV-1/2 gB (H1359) monoclonal antibody is an invaluable tool for researchers investigating the mechanisms of herpes simplex virus infection and the development of antiviral strategies.
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HSV-1/2 gB Antibody (H1359) References:
- Enterocin CRL35 inhibits late stages of HSV-1 and HSV-2 replication in vitro. | Wachsman, MB., et al. 2003. Antiviral Res. 58: 17-24. PMID: 12719003
- Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. | Lyu, SY., et al. 2005. Arch Pharm Res. 28: 1293-301. PMID: 16350858
- Intercellular trafficking and cytotoxicity of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP repeat peptide. | Luo, C., et al. 2007. Virus Genes. 34: 263-72. PMID: 16927131
- Identification of an HSV-1/HSV-2 cross-reactive T cell determinant. | Grammer, SF., et al. 1990. J Immunol. 145: 2249-53. PMID: 1697879
- Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses. | Iyer, AV., et al. 2013. Virol J. 10: 317. PMID: 24165088
- Auto-associative heparin nanoassemblies: a biomimetic platform against the heparan sulfate-dependent viruses HSV-1, HSV-2, HPV-16 and RSV. | Lembo, D., et al. 2014. Eur J Pharm Biopharm. 88: 275-82. PMID: 24835150
- Functional comparison of herpes simplex virus 1 (HSV-1) and HSV-2 ICP27 homologs reveals a role for ICP27 in virion release. | Park, D., et al. 2015. J Virol. 89: 2892-905. PMID: 25540385
- Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene. | Shindo, K., et al. 2016. J Virol. 90: 457-73. PMID: 26491159
- Epitope specificity of H-2Kb-restricted, HSV-1-, and HSV-2-cross-reactive cytotoxic T lymphocyte clones. | Bonneau, RH., et al. 1993. Virology. 195: 62-70. PMID: 7686314
- The novel protein kinase of the RR1 subunit of herpes simplex virus has autophosphorylation and transphosphorylation activity that differs in its ATP requirements for HSV-1 and HSV-2. | Peng, T., et al. 1996. Virology. 216: 184-96. PMID: 8614985
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSV-1/2 gB Antibody (H1359) | sc-69798 | 100 µg/ml | $322.00 |