HspBP1 Antibody (F-11): sc-390467

HspBP1 Antibody (F-11) is a mouse monoclonal IgM antibody that detects HspBP1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HspBP1 antibody (F-11) is available as the non-conjugated form. Hsp70-interacting protein, or HspBP1, plays a crucial role as a nucleotide exchange factor for Hsp70, a chaperone protein essential for proper protein folding and cellular stress response. HspBP1 modulates Hsp70 activity by binding to this chaperone and inhibiting its function, thereby promoting nucleotide dissociation from the Hsp70 ATPase domain. This interaction is vital for protein maturation, such as the cystic fibrosis transmembrane conductance regulator (CFTR), as HspBP1 interferes with CHIP-induced degradation of immature CFTR forms, ultimately enhancing their maturation and functionality. HspBP1 is predominantly expressed in heart and skeletal muscle, highlighting its significance in tissues requiring robust protein quality control mechanisms.

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HspBP1 Antibody (F-11) References:

1. Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70.  |  Raynes, DA. and Guerriero, V. 2000. Biochim Biophys Acta. 1490: 203-7. PMID: 10786638
2. HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an Hsc70 nucleotide exchange factor.  |  Kabani, M., et al. 2002. FEBS Lett. 531: 339-42. PMID: 12417338
3. HspBP1, an Hsp70 cochaperone, has two structural domains and is capable of altering the conformation of the Hsp70 ATPase domain.  |  McLellan, CA., et al. 2003. J Biol Chem. 278: 19017-22. PMID: 12651857
4. Increased expression of the Hsp70 cochaperone HspBP1 in tumors.  |  Raynes, DA., et al. 2003. Tumour Biol. 24: 281-5. PMID: 15004487
5. The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator.  |  Alberti, S., et al. 2004. Mol Biol Cell. 15: 4003-10. PMID: 15215316
6. [Heat shock protein 70 binding protein 1 induces enhanced apoptotic response against anticancer drugs in tumor cells].  |  Tanimura, S. and Kohno, M. 2004. Nihon Rinsho. 62: 1291-6. PMID: 15283146
7. Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.  |  Shomura, Y., et al. 2005. Mol Cell. 17: 367-79. PMID: 15694338
8. Development of a sensitive assay for the measurement of antibodies against heat shock protein binding protein 1 (HspBP1): increased levels of anti-HspBP1 IgG are prevalent in HIV infected subjects.  |  Papp, D., et al. 2005. J Med Virol. 76: 464-9. PMID: 15977250
9. Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression.  |  Gottwald, E., et al. 2006. Cell Biol Int. 30: 553-8. PMID: 16677834

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HspBP1 Antibody (F-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-HspBP1 Antibody (F-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HspBP1 Antibody (F-11) Specifications

Alternate Product Name: HspBP1

Product Clone Name: F-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 346-362

Epitope Target: HspBP1

Epitope Species: human

Product Reactivity/Detection: HspBP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for HspBP1 Antibody (F-11): P: Blocking Peptide