HSPB2 Antibody (F-9): sc-514154
- HSPB2 Antibody (F-9) is a mouse monoclonal IgG1 κ HSPB2 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 36-110 mapping within an internal region of HSPB2 of human origin
- HSPB2 Antibody (F-9) is recommended for detection of HSPB2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-HSPB2 Antibody (F-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HSPB2 Antibody (F-9) for WB applications. These reagents are now offered in bundles with HSPB2 Antibody (F-9) (see ordering information below).
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HSPB2 Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSPB2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HSPB2 (F-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HSPB2, also known as heat shock 27 kDa protein 2 or MKBP, is a 182 amino acid protein that plays a crucial role in cellular stress responses, particularly in heart and skeletal muscle tissues. HSPB2 is primarily localized to mitochondria, where HSPB2 functions as an ATP-dependent chaperone, facilitating the refolding of denatured proteins and maintaining cellular homeostasis. HSPB2 interacts with the actin cytoskeleton, which is vital for cellular integrity and function, and HSPB2 has been implicated in preventing apoptotic cell death, thereby contributing to cell survival under stress conditions. HSPB2 expression is notably elevated in various cancer cell lines, indicating HSPB2′s potential role in tumorigenesis and metastasis, making HSPB2 a significant target for research in cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSPB2 Antibody (F-9) References:
- On the role of Hsp27 in regulating apoptosis. | Concannon, CG., et al. 2003. Apoptosis. 8: 61-70. PMID: 12510153
- hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells. | Mao, H., et al. 2003. J Biol Chem. 278: 18214-20. PMID: 12611892
- Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3. | Wen, FC., et al. 2003. FEBS Lett. 546: 307-14. PMID: 12832059
- HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. | Parcellier, A., et al. 2003. Mol Cell Biol. 23: 5790-802. PMID: 12897149
- Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell. | An, SS., et al. 2004. J Appl Physiol (1985). 96: 1701-13. PMID: 14729728
- Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival. | Shimura, H., et al. 2004. J Biol Chem. 279: 17957-62. PMID: 14963027
- Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. | Havasi, A., et al. 2008. J Biol Chem. 283: 12305-13. PMID: 18299320
- HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion. | Kato, H., et al. 2008. Arch Biochem Biophys. 475: 80-6. PMID: 18471985
- MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. | Suzuki, A., et al. 1998. J Cell Biol. 140: 1113-24. PMID: 9490724
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSPB2 Antibody (F-9) | sc-514154 | 200 µg/ml | $322.00 | |||
HSPB2 Antibody (F-9): m-IgG Fc BP-HRP Bundle | sc-531046 | 200 µg Ab; 10 µg BP | $361.00 | |||
HSPB2 Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-524626 | 200 µg Ab, 40 µg BP | $361.00 | |||
HSPB2 Antibody (F-9): m-IgG1 BP-HRP Bundle | sc-544372 | 200 µg Ab; 20 µg BP | $361.00 | |||
HSPB2 Antibody (F-9) AC | sc-514154 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HSPB2 Antibody (F-9) HRP | sc-514154 HRP | 200 µg/ml | $322.00 | |||
HSPB2 Antibody (F-9) FITC | sc-514154 FITC | 200 µg/ml | $336.00 | |||
HSPB2 Antibody (F-9) PE | sc-514154 PE | 200 µg/ml | $349.00 | |||
HSPB2 Antibody (F-9) Alexa Fluor® 488 | sc-514154 AF488 | 200 µg/ml | $364.00 | |||
HSPB2 Antibody (F-9) Alexa Fluor® 546 | sc-514154 AF546 | 200 µg/ml | $364.00 | |||
HSPB2 Antibody (F-9) Alexa Fluor® 594 | sc-514154 AF594 | 200 µg/ml | $364.00 | |||
HSPB2 Antibody (F-9) Alexa Fluor® 647 | sc-514154 AF647 | 200 µg/ml | $364.00 | |||
HSPB2 Antibody (F-9) Alexa Fluor® 680 | sc-514154 AF680 | 200 µg/ml | $364.00 | |||
HSPB2 Antibody (F-9) Alexa Fluor® 790 | sc-514154 AF790 | 200 µg/ml | $364.00 |