Molecular structure of HSP-990, CAS Number: 934343-74-5
HSP-990 (CAS 934343-74-5)
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Alternate Names:
(R)-2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one
Application:
HSP-990 is an inhibitor of Hsp90
CAS Number:
934343-74-5
Purity:
≥99%
Molecular Weight:
379.39
Molecular Formula:
C20H18FN5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
HSP-990 is an inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp-990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses.
HSP-990 (CAS 934343-74-5) References
- The novel, orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases. | Lamottke, B., et al. 2012. Eur J Haematol. 88: 406-15. PMID: 22309072
- Hsp90 inhibition enhances PI-3 kinase inhibition and radiosensitivity in glioblastoma. | Wachsberger, PR., et al. 2014. J Cancer Res Clin Oncol. 140: 573-82. PMID: 24500492
- PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78. | Moriya, C., et al. 2018. Cancer Sci. 109: 373-383. PMID: 29178343
- Heat shock proteins as a new, promising target of multiple myeloma therapy. | Grosicki, S., et al. 2020. Expert Rev Hematol. 13: 117-126. PMID: 31971027
- Targeting the HSP90-CDC37-kinase chaperone cycle: A promising therapeutic strategy for cancer. | Wang, L., et al. 2022. Med Res Rev. 42: 156-182. PMID: 33846988
- Transcriptomics-Guided In Silico Drug Repurposing: Identifying New Candidates with Dual-Stage Antiplasmodial Activity. | Borba, JVB., et al. 2023. ACS Omega. 8: 34084-34090. PMID: 37744849
Inhibitor of:
HSP 90.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSP-990, 10 mg | sc-364508 | 10 mg | $299.00 | |||
HSP-990, 50 mg | sc-364508A | 50 mg | $930.00 |