HSGT1 Antibody (RZ-17): sc-81860

HSGT1 Antibody (RZ-17) is a mouse monoclonal IgG1 antibody that detects HSGT1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HSGT1 antibody (RZ-17) is available as the non-conjugated format. HSGT1, also known as ECD (ecdysoneless homolog), hECD, or SGT1 (suppressor of GCR2), is a 644 amino acid ortholog of the Drosophila Ecd1 protein, which plays a crucial role in p53 regulation, a key tumor suppressor involved in cell cycle control and apoptosis. Through p53 interaction, HSGT1 enhances stability and functional activity, influencing cellular responses to stress and DNA damage. Proper p53 functioning maintains genomic integrity and prevents tumorigenesis, making HSGT1 significant in cancer biology. HSGT1 expression in heart and skeletal muscle highlights potential importance in muscle physiology and development.

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HSGT1 Antibody (RZ-17) References:

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3. Spsgt1, a new essential gene of Schizosaccharomyces pombe, is involved in carbohydrate metabolism.  |  Kainou, T., et al. 2006. Yeast. 23: 35-53. PMID: 16408318
4. The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function.  |  Zhang, Y., et al. 2006. Cancer Res. 66: 7167-75. PMID: 16849563
5. The ecdysoneless (ecd1ts) mutation disrupts ecdysteroid synthesis autonomously in the ring gland of Drosophila melanogaster.  |  Henrich, VC., et al. 1987. Dev Biol. 120: 50-5. PMID: 3102296
6. Developmental requirements for the ecdysoneless (ecd) locus in Drosophila melanogaster.  |  Henrich, VC., et al. 1993. Dev Genet. 14: 369-77. PMID: 8293578
7. A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae.  |  Sato, T., et al. 1999. Mol Gen Genet. 260: 535-40. PMID: 9928932