HSBP1 Antibody (2C3): sc-517153

HSBP1 Antibody (2C3) is a mouse monoclonal IgG2a kappa light chain antibody that detects HSBP1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HSBP1 antibody (2C3) is available as a non-conjugated format. HSBP1, or heat shock factor-binding protein 1, is a crucial nuclear protein composed of 76 amino acids that plays a significant role in the cellular response to stress. HSBP1 functions primarily as a negative regulator of the heat shock response by binding to heat shock factor 1 (HSF1), which is essential for the transcriptional activation of heat shock genes. Under normal conditions, HSF1 exists as a monomer, but upon stress, HSF1 forms trimers, translocates to the nucleus, and activates the expression of heat shock proteins that help protect cells from damage. The regulation of HSF1 by HSBP1 is vital because HSBP1 ensures that the heat shock response is appropriately modulated, preventing excessive activation that could lead to cellular dysfunction. HSBP1 serves as an important target for studies related to stress responses and cellular protection mechanisms, particularly in the context of diseases where heat shock protein expression is altered.

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HSBP1 Antibody (2C3) References:

1. The maize heat shock factor-binding protein paralogs EMP2 and HSBP2 interact non-redundantly with specific heat shock factors.  |  Fu, S., et al. 2006. Planta. 224: 42-52. PMID: 16331466
2. Transcriptional activation of heat-shock genes in eukaryotes.  |  Tanguay, RM. 1988. Biochem Cell Biol. 66: 584-93. PMID: 3048332
3. Estrogen dependent expression of heat shock transcription factor: implications for uterine synthesis of heat shock proteins.  |  Yang, X., et al. 1995. J Steroid Biochem Mol Biol. 52: 415-9. PMID: 7748806
4. Determination of heat-shock transcription factor 2 stoichiometry at looped DNA complexes using scanning force microscopy.  |  Wyman, C., et al. 1995. EMBO J. 14: 117-23. PMID: 7828583
5. Function and regulation of heat shock factor 2 during mouse embryogenesis.  |  Rallu, M., et al. 1997. Proc Natl Acad Sci U S A. 94: 2392-7. PMID: 9122205
6. Negative regulation of the heat shock transcriptional response by HSBP1.  |  Satyal, SH., et al. 1998. Genes Dev. 12: 1962-74. PMID: 9649501
7. Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway.  |  Mathew, A., et al. 1998. Mol Cell Biol. 18: 5091-8. PMID: 9710593
8. Glycogen synthase kinase 3beta and extracellular signal-regulated kinase inactivate heat shock transcription factor 1 by facilitating the disappearance of transcriptionally active granules after heat shock.  |  He, B., et al. 1998. Mol Cell Biol. 18: 6624-33. PMID: 9774677