Hs68 Cell Lysate: sc-2230

Hs68 Cell Lysate is derived from the Hs68 cell line, a fibroblast cell line extracted from the normal dermal tissue of a human foreskin. This cell line, established in the late 1960s, has become a staple in cellular biology research due to its robust growth characteristics and genetic stability over multiple passages. The lysate itself is produced by lysing Hs68 cells, which involves breaking down the cell membranes to release a comprehensive array of cellular components including proteins, nucleic acids, and various metabolites. This biochemical snapshot allows researchers to delve into the fundamental processes of cell aging, growth, and replication, particularly in the context of human fibroblasts. Hs68 Cell Lysate has been extensively used in research focused on understanding the cellular mechanisms that underpin wound healing, tissue regeneration, and cellular senescence. The lysate provides a valuable resource for studies in proteomics, where it aids in the identification and analysis of protein expression and interaction networks within normal human fibroblasts. Moreover, because of its origin from non-cancerous tissue, it serves as an important control in comparative studies that explore the cellular dynamics of fibroblast behavior in various physiological conditions.

Hs68 Cell Lysate References:

1. Assembly of the type 1 procollagen molecule: selectivity of the interactions between the alpha 1(I)- and alpha 2(I)-carboxyl propeptides.  |  Alvares, K., et al. 1999. Biochemistry. 38: 5401-11. PMID: 10220327
2. Subcellular localization and structural function of endogenous phosphorylated phosphatidylinositol 4-kinase (PI4K92).  |  Szivak, I., et al. 2006. J Biol Chem. 281: 16740-9. PMID: 16606619