HRT3 Antibody (3555C3a): sc-81294

HRT3 Antibody (3555C3a) is a mouse monoclonal IgG1 antibody that detects HRT3 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-HRT3 antibody (3555C3a) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. HRT3 (3555C3a) antibody recognizes a member of the Hairy/Enhancer of split (H/E(spl)) family of transcriptional repressors, which play a crucial role in gene expression regulation during embryonic development. HRT3 is involved in the Notch signaling pathway, which is essential for determining cell fate and establishing boundaries in developing tissues. This protein is primarily located in the nucleus, where HRT3 functions to modulate target gene transcription, thereby influencing processes such as cell differentiation and organogenesis. Understanding HRT3 localization and function is vital, as dysregulation of Notch signaling has been implicated in various developmental disorders and cancers. HRT3′s structural features, including its basic helix-loop-helix (bHLH) domain, enable protein interactions in the Notch signaling pathway, further underscoring its significance in cellular communication and developmental processes. Anti-HRT3 antibody (3555C3a) helps researchers gain insights into the molecular mechanisms underlying these critical biological functions.

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HRT3 Antibody (3555C3a) References:

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2. Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.  |  Leimeister, C., et al. 1999. Mech Dev. 85: 173-7. PMID: 10415358
3. HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.  |  Nakagawa, O., et al. 1999. Dev Biol. 216: 72-84. PMID: 10588864
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5. Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos.  |  Leimeister, C., et al. 2000. Mech Dev. 98: 175-8. PMID: 11044625
6. The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation.  |  Henderson, AM., et al. 2001. J Biol Chem. 276: 6169-76. PMID: 11069914
7. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.  |  Nakagawa, O., et al. 2000. Proc Natl Acad Sci U S A. 97: 13655-60. PMID: 11095750