HRT2 Antibody (2B10): sc-293301

HRT2 Antibody (2B10) is a mouse monoclonal IgG2a kappa light chain antibody that detects HRT2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HRT2 antibody (2B10) is available as a non-conjugated format. HRT2, a member of the Hairy-related transcription factors, plays a crucial role in gene expression regulation during embryonic development through involvement in the Notch signaling pathway. This pathway determines cell fate and establishes boundaries in gene expression, vital for proper tissue and organ formation. HRT2, along with family members HRT1 and HRT3, contains a basic helix-loop-helix (bHLH) domain functioning as a transcriptional repressor, influencing downstream target genes critical for embryonic patterning. HRT2′s structural integrity enables effective interaction with other transcription factors and regulatory proteins, ensuring precise control over developmental processes. HRT2 is located on chromosome 6q21, highlighting genetic significance. Altered HRT2 expression has been implicated in breast, lung, and kidney tumors, making HRT2 a potential biomarker for tumorigenesis and therapeutic target.

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HRT2 Antibody (2B10) References:

1. Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split.  |  Kokubo, H., et al. 1999. Biochem Biophys Res Commun. 260: 459-65. PMID: 10403790
2. Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.  |  Leimeister, C., et al. 1999. Mech Dev. 85: 173-7. PMID: 10415358
3. HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.  |  Nakagawa, O., et al. 1999. Dev Biol. 216: 72-84. PMID: 10588864
4. Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.  |  Steidl, C., et al. 2000. Genomics. 66: 195-203. PMID: 10860664
5. Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos.  |  Leimeister, C., et al. 2000. Mech Dev. 98: 175-8. PMID: 11044625
6. The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation.  |  Henderson, AM., et al. 2001. J Biol Chem. 276: 6169-76. PMID: 11069914
7. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.  |  Nakagawa, O., et al. 2000. Proc Natl Acad Sci U S A. 97: 13655-60. PMID: 11095750

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HRT2 Antibody (2B10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HRT2 Antibody (2B10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HRT2 Antibody (2B10) Specifications

Alternate Product Name: HRT2

Product Clone Name: 2B10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-110

Epitope Target: HRT2

Epitope Species: human

Product Reactivity/Detection: HRT2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HRT2 Antibody (2B10): N/A