Molecular structure of HQNO, CAS Number: 341-88-8
HQNO (CAS 341-88-8)
See product citations (6)
Alternate Names:
HQNO is also known as 2-heptyl-4-quinolinol 1-oxide.
Application:
HQNO is a high affinity respiratory chain inhibitor of quinone oxidation and Zn(II) described to reduce oxygen in and the activity of proton pumps.
CAS Number:
341-88-8
Purity:
≥98%
Molecular Weight:
259.34
Molecular Formula:
C16H21NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
HQNO is a high affinity respiratory chain inhibitor of quinone oxidation and Zn(II). HQNO is also described to inhibit proton channels needed to reduce oxygen and the activity of proton pumps. Additionally, HQNO blocks mitochondrial complex I and III, and the activity of NADH oxidase. Along with aurachin C1–10 it has been shown that HQNO does not change the ubiquinone-8 from the QH site. P. aeruginosa and S. aureus studies report that P. aeruginosa exposed to HQNO stimulates S. aureus to produce small-colony variants and biofilms by activating SigB. Respiratory chain mechanisms such as electron transfer and proton/sodium translocation can be investigated, using HQNO.
HQNO (CAS 341-88-8) References
- Enzymatic properties of the membrane-bound NADH oxidase system in the aerobic respiratory chain of Bacillus cereus. | Kim, MS. and Kim, YJ. 2004. J Biochem Mol Biol. 37: 753-6. PMID: 15607037
- Physiological roles of three Na+/H+ antiporters in the halophilic bacterium Vibrio parahaemolyticus. | Kuroda, T., et al. 2005. Microbiol Immunol. 49: 711-9. PMID: 16113500
- Effects of electron transport inhibitors and uncouplers on the oxidation of ferrous iron and compounds interacting with ferric iron in Acidithiobacillus ferrooxidans. | Chen, Y. and Suzuki, I. 2005. Can J Microbiol. 51: 695-703. PMID: 16234867
- Effects of electron transport inhibitors on iron reduction in Aeromonas hydrophila strain KB1. | Woźnica, A., et al. 2003. Anaerobe. 9: 125-30. PMID: 16887699
- HQNO-sensitive NADH:quinone oxidoreductase of Bacillus cereus KCTC 3674. | Kang, J. and Kim, YJ. 2007. J Biochem Mol Biol. 40: 53-7. PMID: 17244482
- A study of cytochrome bo3 in a tethered bilayer lipid membrane. | Weiss, SA., et al. 2010. Biochim Biophys Acta. 1797: 1917-23. PMID: 20096262
- Staphylococcus aureus sigma B-dependent emergence of small-colony variants and biofilm production following exposure to Pseudomonas aeruginosa 4-hydroxy-2-heptylquinoline-N-oxide. | Mitchell, G., et al. 2010. BMC Microbiol. 10: 33. PMID: 20113519
- The quinone-binding sites of the cytochrome bo3 ubiquinol oxidase from Escherichia coli. | Yap, LL., et al. 2010. Biochim Biophys Acta. 1797: 1924-32. PMID: 20416270
- Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors. | Petri, J., et al. 2018. Biochim Biophys Acta Bioenerg. 1859: 482-490. PMID: 29621505
- Efficient modification of the Pseudomonas aeruginosa toxin 2-heptyl-1-hydroxyquinolin-4-one by three Bacillus glycosyltransferases with broad substrate ranges. | Thierbach, S., et al. 2020. J Biotechnol. 308: 74-81. PMID: 31786106
- Structure of the cytochrome aa3 -600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site. | Xu, J., et al. 2020. Proc Natl Acad Sci U S A. 117: 872-876. PMID: 31888984
- An Immunochemical Approach to Detect the Quorum Sensing-Regulated Virulence Factor 2-Heptyl-4-Quinoline N-Oxide (HQNO) Produced by Pseudomonas aeruginosa Clinical Isolates. | Montagut, EJ., et al. 2022. Microbiol Spectr. 10: e0107321. PMID: 35876587
- Effect of the pseudomonas metabolites HQNO on the Toxoplasma gondii RH strain in vitro and in vivo. | Mo, J., et al. 2023. Int J Parasitol Drugs Drug Resist. 21: 74-80. PMID: 36758272
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HQNO, 10 mg | sc-202654 | 10 mg | $152.00 | |||
HQNO, 50 mg | sc-202654A | 50 mg | $615.00 |