Molecular structure of HQL-79, CAS Number: 162641-16-9
HQL-79 (CAS 162641-16-9)
Alternate Names:
4-benzhydryloxy-1-[3-(2H-tetrazol-5-yl)propyl]piperidine
Application:
HQL-79 is a selective PGE synthase inhibitor
CAS Number:
162641-16-9
Purity:
≥98%
Molecular Weight:
377.48
Molecular Formula:
C22H27N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A selective inhibitor of hematopoietic prostaglandin D (PGD) synthase, that structurally is a synthetic tetrazole compound originally prepared as a possible antihistamine.1 Subsequent evaluation in models of allergy and asthma demonstrates the HQL-79 is orally available, and inhibits the synthesis of PGD2.2 HQL-79 is thus a likely lead compound for the preparation of potent, selective hematopoietic PGD synthase inhibitors.
HQL-79 (CAS 162641-16-9) References
- Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. | Aritake, K., et al. 2006. J Biol Chem. 281: 15277-86. PMID: 16547010
- Inhibition of prostaglandin D synthase suppresses muscular necrosis. | Mohri, I., et al. 2009. Am J Pathol. 174: 1735-44. PMID: 19359520
- Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice. | Liu, M., et al. 2009. Neuroscience. 163: 296-307. PMID: 19531375
- Oesophagostomum dentatum: effect of glutathione S-transferase (GST) inhibitors on GST activity and larval development. | Joachim, A., et al. 2011. Exp Parasitol. 127: 762-7. PMID: 21241694
- [Hematopoietic prostaglandin D synthase inhibitors for the treatment of duchenne muscular dystrophy]. | Kamauchi, S. and Urade, Y. 2011. Brain Nerve. 63: 1261-9. PMID: 22068479
- Prostaglandin D2 Regulates SOX9 Nuclear Translocation during Gonadal Sex Determination in Tammar Wallaby, Macropus eugenii. | Chen, Y., et al. 2017. Sex Dev. 11: 143-150. PMID: 28472794
- Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice. | Song, WL., et al. 2018. J Pharmacol Exp Ther. 367: 425-432. PMID: 30305427
- Leptin Elicits In Vivo Eosinophil Migration and Activation: Key Role of Mast Cell-Derived PGD2. | Amorim, NRT., et al. 2020. Front Endocrinol (Lausanne). 11: 572113. PMID: 33117286
- Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models. | Matsushita, N., et al. 1998. Jpn J Pharmacol. 78: 1-10. PMID: 9804056
- Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. | Matsushita, N., et al. 1998. Jpn J Pharmacol. 78: 11-22. PMID: 9804057
Inhibitor of:
PGD2 synthase, and PGE Synthase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HQL-79, 1 mg | sc-205344 | 1 mg | $35.00 | |||
HQL-79, 5 mg | sc-205344A | 5 mg | $82.00 |