HQL-79 CAS: 162641-16-9
MF: C22H27N5O
MW: 377.48
A selective PGE synthase inhibitor.

HQL-79 (CAS 162641-16-9)

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Synonym: 4-benzhydryloxy-1-[3-(2H-tetrazol-5-yl)propyl]piperidine
Application: A selective PGE synthase inhibitor
CAS Number: 162641-16-9
Purity: ≥98%
Molecular Weight: 377.48
Molecular Formula: C22H27N5O
* Refer to Certificate of Analysis for lot specific data (including water content).
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HQL-79 is a selective inhibitor of PGD (hematopoietic prostaglandin D) synthase (PGE synthase). It is a synthetic tetrazole compound originally prepared as a possible antihistamine. Subsequent evaluation in models of allergy and asthma demonstrates the HQL-79 inhibits the synthesis of PGD2. HQL-79 is thus a likely lead compound for the preparation of potent, selective PGE synthase inhibitors.


References

1. Matsushita, N., et al., 1998. Pharmacological studies on the novel antiallergic drug HQL-79: I. Antiallergic and antiasthmatic effects in various experimental models. Japanese journal of pharmacology. 78(1): 1-10. PMID: 9804056
2. Matsushita, N., et al., 1998. Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. Japanese journal of pharmacology. 78(1): 11-22. PMID: 9804057

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol (~2.5 mg/ml), PBS (pH 7.2), and DMSO (25 mM). Insoluble in water at 25° C.
Storage :
Store at -20° C
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
PGD synthase: IC50 = 1.80 µM (human)
pK Values :
pKa: 4.85 (Predicted), pKb: 8.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6540277
MDL Number :
MFCD00936179
SMILES :
C1CN(CCC1OC(C2=CC=CC=C2)C3=CC=CC=C3)CCCC4=NNN=N4

Download SDS (MSDS)

Certificate of Analysis

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