HPV18 E7 Antibody (718-15): sc-51952
- HPV18 E7 Antibody (718-15) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against full size recombinant E7 protein of HPV papilloma virus type 18
- recommended for detection of the E7 protein of HPV type 18 of HPV origin by WB and ELISA
- See HPV18 E7 (F-7): sc-365035 for HPV18 E7 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HPV18 E7 Antibody (718-15). This work is in progress.
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HPV18 E7 Antibody (718-15) is a mouse monoclonal IgG1 antibody that detects HPV18 E7 in HPV by applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). HPV18 E7 is a crucial oncoprotein that plays a significant role in the development of cervical cancer, particularly in the context of high-risk human papillomavirus infections. HPV18 E7 functions primarily by binding to the retinoblastoma protein (pRB), disrupting pRB′s ability to regulate the cell cycle, which leads to uncontrolled cellular proliferation. The interaction between HPV18 E7 and pRB is vital because HPV18 E7 allows the virus to hijack the host′s cellular machinery, promoting the progression of the cell cycle and contributing to oncogenesis. Understanding the mechanisms of this interaction is essential for developing targeted therapies and vaccines against HPV-related cancers. Anti-HPV18 E7 antibody (718-15) is an invaluable tool for researchers studying the molecular pathways involved in HPV-induced malignancies, enabling the detection and quantification of this oncoprotein in various experimental settings.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HPV18 E7 Antibody (718-15) References:
- Identification of a naturally processed HLA-A*0201 HPV18 E7 T cell epitope by tumor cell mediated in vitro vaccination. | Kather, A., et al. 2003. Int J Cancer. 104: 345-53. PMID: 12569558
- Induction of tumor-specific cytotoxicity in tumor infiltrating lymphocytes by HPV16 and HPV18 E7-pulsed autologous dendritic cells in patients with cancer of the uterine cervix. | Santin, AD., et al. 2003. Gynecol Oncol. 89: 271-80. PMID: 12713991
- Dendritic cell-based tumor vaccine for cervical cancer I: in vitro stimulation with recombinant protein-pulsed dendritic cells induces specific T cells to HPV16 E7 or HPV18 E7. | Nonn, M., et al. 2003. J Cancer Res Clin Oncol. 129: 511-20. PMID: 12905010
- Estrogen contributes to non-pRb targeted HPV18 E7-caused cell proliferation and transformation. | Yan, X., et al. 2010. Cancer Biol Ther. 9: 206-15. PMID: 20009582
- Detection of human papillomavirus type 18 E7 oncoprotein in cervical smears: a feasibility study. | Ehehalt, D., et al. 2012. J Clin Microbiol. 50: 246-57. PMID: 22135254
- [Preparation of HPV18 E7 peptide plus CpG vaccine and its immunologic effects in vitro]. | Liao, SJ., et al. 2012. Zhonghua Yi Xue Za Zhi. 92: 1641-5. PMID: 22944136
- HPV18 E7 induces the over-transcription of eIF4E gene in cervical cancer. | Pang, T., et al. 2015. Iran J Basic Med Sci. 18: 684-90. PMID: 26351560
- DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation. | Lou, M., et al. 2023. J Med Virol. 95: e28310. PMID: 36377393
- HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14. | Blakely, WJ., et al. 2024. mBio. 15: e0181124. PMID: 39248565
- The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia is disrupted in cells expressing HPV18 E7 oncoprotein. | Amellem, O., et al. 1998. Br J Cancer. 77: 862-72. PMID: 9528826
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPV18 E7 Antibody (718-15) | sc-51952 | 100 µg/ml | $316.00 |