HPK1 Antibody (C-9): sc-376169

HPK1 Antibody (C-9) is a mouse monoclonal IgG2b antibody that detects HPK1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HPK1, or hematopoietic progenitor kinase 1, is a crucial serine/threonine kinase that plays a significant role in the regulation of the stress-responsive JNK/SAPK signaling pathway, which is vital for cellular responses to stress and inflammation. Located primarily in the cytoplasm, HPK1 interacts with various signaling molecules, including MEKK, to modulate the activity of downstream kinases, thereby influencing cellular processes such as apoptosis, differentiation, and proliferation. The proper functioning of HPK1 is essential for maintaining cellular homeostasis and responding to external stimuli, making HPK1 a key player in various physiological and pathological conditions. With an ability to activate the JNK signaling pathway, HPK1 is implicated in numerous diseases, including cancer and autoimmune disorders, highlighting the importance of studying HPK1 for therapeutic interventions. Anti-HPK1 antibody (C-9) provides a reliable tool for researchers aiming to explore the intricate signaling networks involving HPK1 and its role in health and disease.

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HPK1 Antibody (C-9) References:

1. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1.  |  Liou, J., et al. 2000. Immunity. 12: 399-408. PMID: 10795738
2. Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death.  |  Brenner, D., et al. 2005. EMBO J. 24: 4279-90. PMID: 16341093
3. Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes.  |  Brenner, D., et al. 2007. Blood. 110: 3968-77. PMID: 17712048
4. Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.  |  Brenner, D., et al. 2009. Proc Natl Acad Sci U S A. 106: 14508-13. PMID: 19706536
5. HPK1 positive expression associated with longer overall survival in patients with estrogen receptor-positive invasive ductal carcinoma‑not otherwise specified.  |  Wang, J., et al. 2017. Mol Med Rep. 16: 4634-4642. PMID: 28765906
6. Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).  |  Chan, BK., et al. 2022. ACS Med Chem Lett. 13: 84-91. PMID: 35059127
7. Discovery of Pyrazolopyridine Derivatives as HPK1 Inhibitors.  |  Ye, Q., et al. 2023. ACS Med Chem Lett. 14: 5-10. PMID: 36655125
8. Theoretical Studies on Selectivity of HPK1/JAK1 Inhibitors by Molecular Dynamics Simulations and Free Energy Calculations.  |  Ge, H., et al. 2023. Int J Mol Sci. 24: PMID: 36768974
9. Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors.  |  Zhang, J., et al. 2023. Bioorg Chem. 140: 106811. PMID: 37659145
10. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.  |  Hu, MC., et al. 1996. Genes Dev. 10: 2251-64. PMID: 8824585

The preferred HPK1 antibody is HPK1 Antibody (G-9): sc-374183.